EGCG对肿瘤干细胞抑制效应研究进展  

Progress in EGCG Functioned on Cancer Stem Cells

作　　者：陈磊[1,2] 李开鸣 马会景 曾宪思[1,2] 贾金婧[1,2] 宋新强[1,2] 

机构地区：[1]信阳师范学院生命科学学院,河南信阳464000 [2]信阳师范学院河南省茶树生物学重点实验室,河南信阳464000 [3]信阳师范学院图书馆,河南信阳464000

出　　处：《信阳师范学院学报（自然科学版）》2018年第1期145-151,共7页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(81502312;31600837);信阳师范学院博士科研启动基金(0201305)

摘　　要：表没食子儿茶素没食子酸酯((-)-Epigallocatechin-3-gallate,EGCG)是绿茶主要活性成分之一,对肿瘤干细胞(Cancer stem cells,CSCs)具备抑制效应.综述了EGCG对CSCs迁移侵袭性、耐药性、自我更新和致瘤性等病理学特性的抑制效应及应用新策略,并对相应信号传导通路进行阐述,为深入研究EGCG抗癌的药理学效应及应用新策略提供借鉴.（-）-Epigallocatcchin-3-gallate （EGCG）, a major bioactive constituent in green tca？ possesses anti- carcinogcnic potential in different tumors. Recent data also showed that EGCG displayed its anti-canccr activityby targeting CSCs. This review focusses on the studies of EGCG functioned on characteristics, including migra-tion and invasion, anti-chcmothcrapy, self-renewal and tumorigcnicity. In addition, signaling pathways, inclu-ding Wnt/β-catcnin, Hedgehog,Notch and AKT pathways,involved in these progress were discussed to pro-vide options for cancer and treatment.

关 键 词：EGCG 肿瘤干细胞 自我更新 迁移性 致瘤性 综述 

分 类 号：R73-3[医药卫生—肿瘤]