全覆膜分节食管内照射支架初步应用  

Clinical application of fully-covered segmented esophageal internal irradiation stent : preliminary results

作　　者：李俊超 张开贤[3] 王超[1] 陆建[1] 王勇[1] 陈荔[1] 朱光宇[1] 郭金和[1] 

机构地区：[1]东南大学附属中大医院介入与血管外科,南京210009 [2]东南大学医学院 [3]山东省滕州市中心人民医院肿瘤科

出　　处：《介入放射学杂志》2018年第1期45-49,共5页Journal of Interventional Radiology

基　　金：江苏省重点研发计划(社会发展)(BE2016783)

摘　　要：目的探讨食管癌患者全覆膜分节食管内照射支架与普通食管内照射支架术后生存时间及并发症等方面差异。方法回顾性分析66例置入食管内照射支架的食管癌患者,分为全覆膜分节食管内照射支架组30例(实验组)和普通食管内照射支架组36例(对照组),就两组病例术后的再狭窄、支架移位、胸痛等并发症情况及生存时间进行对照研究。以P<0.05为有统计学意义。结果实验组与对照组再狭窄率无统计学意义(20.0%比30.6%,P=0.403);但实验组较对照组中位再狭窄发生时间延长(161.5 d比138 d,P=0.025)。实验组较对照组移位率增高(33.3%比8.3%,P=0.014),两组中位移位发生时间无统计学意义(91.5 d比166 d,P=0.236)。两组中位生存时间无统计学意义(186 d比178 d,P=0.486)。两组在其他支架相关并发症方面差异无统计学意义。结论全覆膜分节食管内照射支架可以延缓支架再狭窄发生时间,但一定程度上增加了移位率。Objective To investigate the differences in the survival time and the occurrence of complications between esophageal cancer patients treated with fully-covered segmented esophageal internal irradiation stent and esophageal cancer patients treated with conventional esophageal internal irradiation steut. Methods The clinical data of 66 esophageal cancer patients, who had received esophageal internal irradiation stents placement, were retrospectively analyzed. The patients were divided into the study group （using fully- covered segmented esophageal internal irradiation stent, n=30） and the control group （using conventional esophageal internal irradiation stent, n =36）. The postoperative complications, including restenosis, stent migration, chest pain, etc., and the survival time of the two groups were recorded. The results were analyzed, and P〈0.05 was considered to be statistically significant. Results No statistically significant difference in the restenosis rate existed between the study group and the control group （20.0% vs. 30.6%,P=0.403） ; although the median time of restenosis in the study group was longer than that in the control group （161.5 d vs. 138 d, P=0.025）. The stent migration rate in the study group was higher than that in the control group （33.3% vs. 8.3%,P=0.014）. The difference in the median time of stent migration between the two groups was not statistically significant （91.5 d vs. 166 d,P=0.236）. No statistically significant difference in the median survival time existed between the two groups （186 d vs. 178 d,P=0.486）. No statistically significantly differences in the incidence of other stent-related complications existed between the two groups. Conclusion Fully-covered segmented esophageal internal irradiation stent can delay the occurrence of restenosis, although it can increase the stent migration rate to a certain degree.（J Intervent Radiol, 2018, 27： 45-49）

关 键 词：支架 食管癌 ^125I粒子 并发症 

分 类 号：R735.3[医药卫生—肿瘤]