循环肿瘤DNA检测及其在乳腺癌中的临床应用  

Detection of circulating tumor DNAs and its application in breast cancer

作　　者：朱彦辉 姚广裕[1] 陈路嘉[1] 胡晓磊[1] 叶长生[1] 

机构地区：[1]南方医科大学南方医院乳腺科,广东广州510515

出　　处：《肿瘤》2018年第1期73-77,共5页Tumor

摘　　要：随着检测技术的精进,循环肿瘤DNA在肿瘤的早期诊断、预后评估、疗效及肿瘤负荷监测等方面有着非常广阔的应用前景。循环肿瘤DNA在乳腺癌中的应用也成为近年来的研究热点,特别是在乳腺癌的早期诊断、肿瘤负荷以及耐药方面。同时,乳腺癌的化疗、靶向治疗和内分泌治疗将更加个体化及针对性。现有的影像学检查和临床检验为乳腺癌综合治疗提供的个体化信息比较有限,而循环肿瘤DNA检测的优势极有可能改变乳腺癌现有的治疗策略,为患者提供更精准的治疗。With the development of detection technology, circulating tumor DNAs have broad application prospects in early diagnosis, prognosis evaluation and curative effect and tumor load monitoring. The application of circulating tumor DNAs in breast cancer has also become a hotspot in recent years, especially in the early diagnosis of breast cancer, tumor burden and drug resistance. At the same time, chemotherapy, targeted therapy, and endocrine therapy for breast cancer will be more individualized and targeted. The existing imaging and clinical tests provide limited individualized information for comprehensive treatment of breast cancer. The advantage of circulating tumor DNA detection is likely to change the existing treatment strategies of breast cancer and provide more precise treatment for patients.

关 键 词：乳腺肿瘤 肿瘤细胞 循环 肿瘤负荷 诊断 预后 

分 类 号：R737.9[医药卫生—肿瘤]