血清NT-ProBNP水平对表征急性脑梗死患者左心室舒张功能损伤程度的诊断价值  

Relationship of NT-ProBNP and IVRT and Ea/Aa in patients with acute cerebral infarction

作　　者：刘璟霞 王朝阳[1] 王玉杰[1] 

机构地区：[1]内蒙古医科大学附属医院急诊科,呼和浩特010050

出　　处：《实用医学杂志》2018年第1期103-106,共4页The Journal of Practical Medicine

摘　　要：目的探讨急性脑梗死患者氨基末端B型脑利钠肽原(NT-Pro BNP)与左心室等容舒张时间(IVRT)和二尖瓣环舒张早期心肌峰值运动速度/二尖瓣环舒张晚期心肌峰值运动速度(Ea/Aa)的相关性。方法选择2015年2月至2016年5月内蒙古医科大学附属医院收治的急性脑梗死患者67例作为观察组和体检健康者60例作为对照组,测定两组血清NT-pro BNP水平和心脏超声参数。对NT-Pro BNP与左心室舒张功能进行相关性分析,并用ROC曲线分析了NT-Pro BNP应用于评估左心室舒张功能的价值。结果与对照组相比,观察组的IVRT和NT-Pro BNP显著提高(t=5.844、7.947,P=0.005、0.000),而Ea/Aa显著降低(t=4.639,P=0.012)。单因素相关分析显示NT-Pro BNP与IVRT显著正相关(r=0.507,P=0.001);与Ea/Aa显著负相关(r=-0.592,P<0.001)。多元线性回归分析提示NT-Pro BNP与IVRT、Ea/Aa独立相关(标准化β=541.90、26.38)。ROC预测结果显示,NT-pro BNP(截止值为426 pg/m L)在检测Ea/Aa<1.0的急性脑梗死患者具有最佳灵敏度(100%)和特异性(100%)。结论血清NT-Pro BNP水平能够有效表征急性脑梗死患者的左心室舒张功能损伤程度。Objective To investigate the relationship of NT-ProBNP, IVRT and Ea/Aa in patients with acute cerebral infarction. Methods From February 2015 to May 2016, 67 patients with acute cerebral infarction and 60 healthy subjects were selected as observation group and control group. Sserum NT-proBNP levels and cardi- ac ultrasound parameters of the two groups were measured. The correlation between NT-ProBNP and left ventricular diastolic function was analyzed, and the ability of NT-ProBNP to detect left ventricular diastolic function was as- sessed with the ROC curve analysis. Results Compared with those in control group, IVRT and NT-ProBNP of ob- servation group were significantly increased （t = 5.844, 7.947, P = 0.005, 0.000）, while Ea/Aa was significantly lower （t = 4.639, P = 0.012）. Correlation analysis showed that there was a significant positive correlation between NT-ProBNP and IVRT （r = 0.507, P = 0.001 ）, and a remarkably negative correlation between NT-ProBNP and Ea/ Aa （r = -0.592, P 〈0.001 ） Multiple linear regression analysis showed that NT-ProBNP was independently correlat- ed with IVRT and Ea/Aa （β= 541.90, 26.38）. ROC predictive results showed that NT-proBNP had the most optimal sensitivity （ 100% ） and specificity （ 100% ） for detecting Ea/Aa 〈 1.0 in patients with acute cerebral infarction. Conclusion Serum NT-ProBNP levels can indirectly reflect the severity of left ventricular diastolic dysfunction in patients with acute cerebral infarction.

关 键 词：急性脑梗死 NT-PROBNP IVRT Ea/Aa 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]