内皮素系统多靶点干预对急性缺血性脑卒中低灌注改善作用的研究进展  

Recent advance in effect of endothelin multi-target intervention on improving low perfusion in acute ischemic stroke

作　　者：史颖 何明利 

机构地区：[1]徐州医科大学附属连云港市第一人民医院神经内科,连云港222002

出　　处：《中华神经医学杂志》2018年第1期39-42,共4页Chinese Journal of Neuromedicine

摘　　要：缺血性脑卒中的高发病率、高死亡率及高致残率已给患者的健康及其家庭、社会的经济造成了严重负担。及时有效地恢复脑血流是治疗急性缺血性脑卒中的关键。内皮素在缺血性脑卒中的病理生理过程中发挥着重要作用。笔者现就内皮素及其受体在脑缺血后的相应变化，结合其信号通路中相应靶点的研究情况作一综述。并提出一些可供进一步研究的新思路。The high morbidity, high mortality and high disabling rate of ischemic stroke have caused a serious burden on health of patients and economy of their families and society. Timely and effective recovery of cerebral blood flow is the key to the treatment of acute ischemic stroke. Endothelin plays an important role in the pathophysiology of cerebral ischemic stroke. In this paper, the changes of endothelin and its receptor after cerebral ischemia, combined with the current research situation of the corresponding target in the signal pathways, are reviewed, and some new ideas for further study are proposed.

关 键 词：内皮素 内皮素受体 缺血性脑卒中 低灌注 干预靶点 

分 类 号：R743.3[医药卫生—神经病学与精神病学]