颞叶癫痫患者的睡眠特征研究  

Study of sleep features in patients with temporal lobe epilepsy

作　　者：毛汕 潘立平[1] 任艳苹[1] 曹娟[1] 吴丹 宋毅军[1] 

机构地区：[1]天津医科大学总医院神经内科,天津市神经病学研究所,300052 [2]天津医科大学宝坻临床学院神经内科

出　　处：《天津医药》2018年第1期70-73,共4页Tianjin Medical Journal

基　　金：天津市应用基础与前沿技术研究计划(14JCZDJC35400);2016年度天津市“131”创新型人才团队培养工程

摘　　要：目的通过多导睡眠监测(PSG)研究颞叶癫痫(TLE)患者发作间期的睡眠特征。方法选取25例TLE患者为TLE组,健康志愿者18例为对照组,对2组受试者分别进行PSG,监测指标包括总卧床时间(TIB)、总睡眠时间(TST)、睡眠效率(SE)、睡眠潜伏期(SL)、快速动眼睡眠期潜伏期(REML)、入睡后觉醒时间(WASO)、非快速动眼睡眠(NREM)1、2、3期以及快速动眼睡眠期(REM)时间占总睡眠期时间的百分比(以N1%、N2%、N3%、REM%表示)、呼吸暂停低通气指数(AHI)、低通气指数、平均血氧饱和度(Sp O_2)及最低Sp O_2、觉醒指数、每小时周期性肢体运动指数(PLMs/h)、每小时REM期PLMs、总睡眠期转换次数(SSS)、每小时睡眠期转换次数(SSS/H)、NREM1、2、3期以及REM、清醒期转换次数(以N1、N2、N3、REM、W表示)、N1、N2、N3、REM、清醒期转换次数占总睡眠期转换次数百分比(以N1/SSS、N2/SSS、N3/SSS、REM/SSS、W/SSS表示)等睡眠指标。结果与对照组相比,TLE组WASO延长,平均Sp O_2降低,PLMs增多,REM期PLMs增多,SSS、SSS/H及N2增多(P<0.05)。结论 TLE患者存在睡眠障碍,主要表现为睡眠结构明显紊乱,睡眠相关呼吸、运动事件增多。Objective To study sleep characteristics in patients with temporal lobe epilepsy(TLE) throughpolysomnography(PSG).MethodsTwenty-five TLE patients(TLE group) and eighteen healthy volunteer subjects(controlgroup) were recruited to our study. Patients of two groups were evaluated by whole-night PSG, including total time in bed(TIB), total sleep time(TST), sleep efficiency(SE), sleep latency(SL), rapid eye movement latency(REML), wake after sleeponset(WASO), the percentages of non-REM(NREM) 1, 2 and 3 stages and the percentages of rapid eye movement(REM)occupied TST(N1%, N2%, N3% and REM%), the apnea-hypopnea index(AHI), hypopnea index, mean oxygen saturation(Sp O_2) and nadir Sp O_2, periodic leg movements(PLMs) index and PLMs index of REM sleep, sleep stage shifts(SSS) andsleep stage shifts per hour(SSS/h), NREM1, NREM2, NREM3 and REM sleep stage and wake shifts(abbreviated as N1, N2,N3, REM and W) and their proportions of SSS(abbreviated as N1/SSS, N2/SSS, N3/SSS, REM/SSS and W/SSS).Results Compared with control group, WASO, PLMs, PLMs index of REM sleep, SSS, SSS/H and N2 were significantly increased inTLE group. Moreover, compared with control group, Sp O_2 was decreased in TLE group(P<0.05).ConclusionOur resultssuggest that TLE patients have sleep disorder manifested as disorder of sleep structure, increased incidents of respiratory andmotion events.

关 键 词：癫痫 颞叶 睡眠障碍 多导睡眠监测 睡眠结构 睡眠相关事件 

分 类 号：R742.1[医药卫生—神经病学与精神病学]