调强放疗联合奈达铂治疗宫颈癌腹主动脉旁淋巴结转移疗效观察  

Clinical Study of Intensity Modulated Radiation Therapy Combine With Nedaplatin in Treatment of Cervical Cancer Patients With Paraaortic Lymph Node Metastasis

作　　者：林娴[1] 李慧灵[1] 郭月新 

机构地区：[1]福建省肿瘤医院妇科,福建福州350014

出　　处：《中国卫生标准管理》2017年第28期64-66,共3页China Health Standard Management

摘　　要：目的观察三维调强适形放疗联合不同剂量奈达铂化疗治疗宫颈癌腹主动脉旁淋巴结转移的疗效和不良反应。方法将52例宫颈癌腹主动脉旁淋巴结转移患者分为观察组(三维适形调强放疗+奈达铂小剂量周化疗)和对照组(三维适形调强放疗+奈达铂常规剂量化疗),每组26例。对比治疗效果及不良反应。结果两组患者治疗近期有效率相似,对照组和观察组出现白细胞低下的患者分别为23例(88.5%)和16例(61.5%),差异有统计学意义(P<0.05),其余贫血、血小板低下、消化道反应、肝功能损害差异无统计学意义。结论 IMRT联合不同剂量奈达铂化疗对宫颈癌腹主动脉旁淋巴结转移的患者近期效果相当,但小剂量周疗患者毒性反应相对较小,值得推广。Objective To evaluate the efficacy and toxicities of intensity modulated radiation therapy（IMRT）with different dose of nedaplatin in the treatment of cervical cancer patients with para-aortic lymph node（PALN）. Methods 52 cases of cervical cancer patients with para-aortic lymph node metastasis were divided into observation group（intensity modulated radiation therapy combine with nedaplatin low-dose weekly treatment ） and concrol group（intensity modulated radiation therapy combine with nedaplatin routine dosage） , 26 cases in each group, the treatment effect and adverse reaction of two groups were compared. Results Two group of patients with similar efficacy in the near future. There were 23 cases （88.5%） and 16 cases （61.5%） in the control group and the observation group with leukopenia, the difference was statistically signifcant （P 〈 0.05）, the remaining anemia, thrombocytopenia, digestive tract reaction , liver dysfunction, the difference was not statistically significant. Conclusion IMRT combined with different doses of nedaplatin chemotherapy in cervical cancer patients with paraaortic lymph node metastasis near future effect is similar, but the low-dose nedaplatin chemotherapy patients with relatively small toxicity, it is worth promoting.

关 键 词：宫颈癌 腹主动脉旁淋巴结转移 调强放疗 奈达铂 

分 类 号：R737.33[医药卫生—肿瘤]