慢性酒精中毒性肝病干预治疗CDT及血清酶学临床分析  

Clinical Analysis of CDT and Serum Enzymology in the Treatment of Chronic Alcoholic Liver Disease

作　　者：孙成山[1] 曾显坤 党彤[2] 孟宪梅[2] 

机构地区：[1]内蒙古通辽市医院消化内科,内蒙古通辽028000 [2]包头医学院第二附属医院消化内科,内蒙古包头014030

出　　处：《中国继续医学教育》2018年第1期71-73,共3页China Continuing Medical Education

摘　　要：目的探讨酒精性肝病患者干预治疗前后血清CDT及生化指标变化情况。方法对106例酒精性肝病患者戒酒前和戒酒2、4周时糖CDT、GGT、ALT和AST水平及糖缺失转铁蛋白百分比(CDT%),对结果进行统计学分析。结果随着患者干预治疗时间的延长,血清CDT、CDT%、GGT水平下降(P<0.05)。与戒酒前相比,戒酒2周和戒酒4周血清酶学水平降低(P<0.05)。结论长期饮酒者血清GGT、CDT、CDT%水平随戒酒时间延长降低,GGT水平易受其他因素影响。因此,血清CDT及CDT%水平可用于酒精性肝病患者干预治疗情况的长期监控。Objective To investigate the changes of serum CDT and biochemical indexes in patients with alcoholic liver disease before and after intervention. Methods The levels of glucose CDT, GGT, ALT and AST and the percentage of glucose defcient transferrin （CDT%） were observed in 106 patients with alcoholic liver disease before and at 2 and 4 weeks, and the percentage of glucose deficient transferrin （CDT%）, the results were statistically analyzed. Results The level of serum CDT, CDT% and GGT decreased with the duration of intervention treatment （P 〈 0.05）. Compared with alcohol abstinence, the level of serum enzyme in 2 weeks and 4 weeksof alcohol abstinence decreased （P 〈 0.05）. Conclusion The level of GGT, CDT and CDT% in the sera of long-term drinkers decreased with the prolongation of alcohol abstinence time, and the level of GGT was easily afected by other factors, therefore, it can be used for long-term monitoring of intervention treatment in patients with alcoholic liver disease.

关 键 词：酒精性肝病 糖缺失转铁蛋白 7-谷氨酰转肽酶 血清酶学 

分 类 号：R575[医药卫生—消化系统]