端粒长度与动脉粥样硬化性脑梗死及斑块稳定性的相关研究  

Relationship between telomere length and atherosclerotic cerebral infarction and plaque stability

作　　者：李丹青 李淮玉 李静[2] 张梅[2] 

机构地区：[1]安徽医科大学附属省立医院神经内科,安徽合肥230001 [2]淮南市第一人民医院神经内科,安徽淮南232000

出　　处：《安徽医药》2018年第2期261-265,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨端粒长度与动脉粥样硬化性脑梗死及颈动脉斑块稳定性之间是否相关。方法选取急性前循环动脉粥样硬化型脑梗死患者70例作为观察组并根据超声结果将其分为稳定斑块组及不稳定斑块组,同时选取健康体检者68例作为对照组。通过实时荧光定量PCR法测定外周血白细胞端粒长度。比较观察组与对照组以及稳定斑块组与不稳定斑块组的端粒长度是否存在差异。结果观察组与对照组的外周血白细胞端粒长度差异有统计学意义(P<0.05)。不稳定斑块组与稳定斑块组外周血端粒长度差异有统计学意义(P<0.05)。结论端粒长度与动脉粥样硬化性脑梗及动脉粥样硬化斑块稳定性之间有相关性。Objective To investigate the relationship between telomere length and atherosclerotic cerebral infarction and plaque stability. Methods Seventy patients with acute cerebral infarction were randomly divided into stable plaque group and unstable plaque group. Sixty-eight healthy subjects were selected as the control group. The telomere length of peripheral blood leukocytes was determined by real-time fluorescence quantitative PCR. There was a difference in the telomere length between the case group and the control group and the stable plaque group and the unstable plaque group. Results The telomere length of peripheral blood leukocytes in the case group and the control group was statistically significant(P <0. 05). There was a significant difference in telomere length between the unstable plaque group and the stable plaque group(P<0.05). Conclusion There is a correlation between telomere length and the stability of atherosclerotic cerebral infarction and atherosclerotic plaque.

关 键 词：外周血白细胞 端粒长度 动脉粥样硬化性脑梗死 颈动脉斑块 稳定性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]