头孢硫脒在Beagle犬的药代动力学  

Pharmacokinetics of cefathiamidine in Beagle dogs

作　　者：张朴[1] 魏敏吉[1] 孔申申[2] 

机构地区：[1]北京大学第一医院临床药理研究所,北京100034 [2]北京大学第一医院动物实验室,北京100034

出　　处：《中国临床药理学杂志》2018年第2期161-164,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的研究头孢硫脒在Beagle犬的药代动力学。方法 6只Beagle犬,雌雄各半,单剂量静脉推注头孢硫脒60 mg·kg^(-1)。用液相-串联质谱法测定Beagle犬血浆样本中头孢硫脒的浓度;用Win Nonlin程序计算药代动力学参数。结果头孢硫脒的主要药代动力学参数:t1/2为(0.42±0.04)h;tmax为(6.00±4.00)×10-2h;Cmax为(302.47±35.39)μg·mL^(-1);AUC0-t为(137.48±31.79)μg·mL^(-1)·h;AUC0-inf为(137.69±31.20)μg·mL^(-1)·h。结论头孢硫脒在Beagle犬中具有快速消除的特点。Objective To study the pharmacokinetics of cefathiamidine in Beagle dogs. Methods Six Beagle dogs received cefathiamidine at a single injection of 60 mg·kg-1. The concentrations of cefathiamidine in plasma were determined by a validated HPLC - MS/MS. The pharmaco- kinetics parameters were calculated by using WinNonlin program. Results After a single injection of 60 mg ·kg-l cefathiamidine, the pharmacokinetics parameters for cefathiamidine were as follows： t1/2为（0.42±0.04）h;tmax为（6.00±4.00）×10-2h;Cmax为（302.47±35.39）μg·m L-1;AUC0-t为（137.48±31.79）μg·m L-1·h;AUC0-inf为（137.69±31.20）μg·m L-1·h. Conclusion Cefathiamidine shows fast elimination characteristics.

关 键 词：头孢硫脒 药代动力学 液相-串联质谱法 

分 类 号：R978.1[医药卫生—药品]