阿那曲唑和他莫昔芬对绝经后激素受体阳性转移性乳腺癌患者的疗效及肿瘤相关炎性因子的影响对比  

Effects of anadrazole and tamoxifen on efficacy and tumor-associated inflammatory factors in hormone receptor-positive patients with metastatic breast cancer after menopause

作　　者：童刚领[1] 程勃然 陈晓秋[1] 吴烜[1] 申东兰[1] 彭安[1] 王树滨[1] 

机构地区：[1]北京大学深圳医院肿瘤内科,广东省深圳市518036

出　　处：《广西医学》2018年第1期4-6,共3页Guangxi Medical Journal

基　　金：广东省自然科学基金(2016A030313381);广东省深圳市战略新兴产业发展专项基金(JCYJ20150529151839281);广东省深圳市卫生计生系统科研项目(201402025)

摘　　要：目的比较阿那曲唑和他莫昔芬对绝经后激素受体阳性转移性乳腺癌[HR(+)MBC]患者的疗效及血清肿瘤相关炎性因子表达水平的影响。方法选取50例HR(+)MBC患者,其中使用芳香化酶抑制剂阿那曲唑治疗者26例(阿那曲唑组),使用传统药物他莫昔芬治疗者24例(他莫昔芬组),比较患者的治疗效果以及治疗前后血清白细胞介素(IL)-1、IL-2、IL-6、IL-8、IL-10和肿瘤坏死因子-α(TNF-α)的表达水平。结果阿那曲唑组的临床疗效优于他莫昔芬组(P<0.05)。治疗后,他莫昔芬组IL-1、IL-8、IL-10和TNF-α水平较治疗前下降(均P<0.05),阿那曲唑组IL-1、IL-8、IL-10、TNF-α水平较治疗前降低(均P<0.05),阿那曲唑组IL-1、IL-2、IL-6、IL-8、IL-10、TNF-α水平均低于他莫昔芬组(均P<0.05)。结论阿那曲唑对HR(+)MBC的疗效优于他莫昔芬;两种药物对肿瘤生长相关炎性因子表达水平的影响存在差异,而这种差异可能与疗效密切相关。Objective To Compare the effects of anadrazole and tamoxifen on the efficacy and expression levels of serum tumor-associated inflammatory factors in patients with hormone receptor-positive metastatic breast cancer[HR（ ＋） MBC]after menopause. Methods Of 50 patients with HR（ ＋） MBC involved,26 patients（ anadrazole group） were administered aromatase inhibitor,anadrazole,and 24 patients（ tamoxifen group） were administered traditional medicine,tamoxifen. The therapeutic efficacy and the expression levels of serum interleukin（ IL）-1,IL-2,IL-6,IL-8,IL-10 and tumor necrosis factor-α（ TNF-α） before and after treatment were compared between the two groups.Results The clinical efficacy of the anastrozole group was significantly superior to that of the tamoxifen group（ P〈0. 05）. After treatment,the levels of IL-1,IL-8,IL-10 and TNF-α decreased in the tamoxifen group compared to the levels before treatment（ all P〈0. 05）,the levels of IL-1,IL-8,IL-10 and TNF-α decreased in the anadrazole group compared to the levels before treatment（ all P〈0. 05）,and the levels of IL-1,IL-2,IL-6,IL-8,IL-10 and TNF-α were lower in the anadrazole group than those in the tamoxifen group（ all P〈0. 05）. Conclusion The efficacy of anastrozole is superior to that of tamoxifen for HR（ ＋） MBC. There is a difference in the effect on the expression levels of tumor-associated inflammatory factors between the two medicines,and that difference might be related to the efficacy closely.

关 键 词：转移性乳腺癌 激素受体阳性 绝经 阿那曲唑 他莫昔芬 炎性因子 

分 类 号：R737.9[医药卫生—肿瘤]