血氨、透明质酸、Ⅲ型前胶原在肝硬化合并肝癌中的应用价值分析  

Analysis of application value of blood ammonia,hyaluronic acid and type Ⅲ procollagen in liver cirrhosis with hepatocellular carcinoma

作　　者：杨敏[1] 刘明全[1] 

机构地区：[1]成都医学院第一附属医院检验科,四川成都610500

出　　处：《中国卫生检验杂志》2017年第24期3579-3580,3582,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血氨(NH_3)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)在肝硬化合并肝癌中的临床价值。方法选取本院2015年1月-2016年1月确诊为肝硬化合并肝癌患者36例作为研究组,另选取同期健康体检者30例作为对照组,采用连续监测法检测入检者NH_3水平,采用化学发光法检测入检者HA、PCⅢ水平,比较2组上述指标变化,并分析肝硬化合并肝癌Child-Pugh不同分级患者的NH_3与体内血清HA、PCⅢ水平的关系。结果研究组体内血清NH_3、HA、PCⅢ水平均较对照组高;研究组Child-Pugh A、B、C级患者中NH_3、HA、PCⅢ水平均高于对照组,差异均有统计学意义(P<0.05)。Pearson直线相关分析发现,Child-Pugh A级肝癌患者的NH_3与其HA、PCⅢ水平呈正相关(P<0.05),而Child-Pugh B、C级肝癌患者的NH_3与其HA、PCⅢ水平无相关性(P>0.05)。结论 NH_3、HA、PCⅢ水平在肝硬化合并肝癌诊断中具有良好的临床价值。Objective To investigate the clinical value of blood ammonia（ NH3）,hyaluronic acid（ HA） and type Ⅲ procollagen（ PCⅢ） in liver cirrhosis with hepatocellular carcinoma. Methods Thirty-six patients with hepatocellular carcinoma（ HCC）diagnosed in our hospital from January 2015 to January 2016 were selected as the study group,while 30 healthy subjects were selected as the control group. The levels of NH3 were measured by continuous monitoring method,and the levels of HA and PCⅢwere measured by chemiluminescence method,then the changes of these indexes were compared. The relationship between NH3 and serum levels of HA and PCⅢ in patients with different Child-Pugh grades and liver cirrhosis combined with hepatocellular carcinoma. Results The levels of NH3,HA and PCⅢ in the study group were higher than those in the control group. The levels of NH3,HA and PCⅢ in the Child-Pugh A,B and C patients were higher than those in the control group,with the differences statistically significant（ P〈0. 05）. Pearson linear correlation analysis found that the NH3 level in Child-Pugh A liver cancer patients was positively correlated with the level of HA and PCⅢ（ P〈0. 05）,while,the levels of NH3 in Child-Pugh B and C-stage hepatocellular carcinoma were not significantly correlated with HA and PCⅢ（ P〉0. 05）. Conclusion NH3,HA and PCⅢ levels have good clinical value in the diagnosis of liver cirrhosis with hepatocellular carcinoma.

关 键 词：肝硬化 肝癌 血氨 透明质酸 Ⅲ型前胶原 

分 类 号：R735.7[医药卫生—肿瘤]