强直性脊柱炎并发葡萄膜炎患者HLA-B27阳性率及相关因素的临床分析  

Clinical analysis of HLA-B27 positive rate and related factors in patients with ankylosing spondylitis complicated with uveitis

作　　者：李元元[1] 陈梦平[1] 丁超[2] 申占省 

机构地区：[1]郑州市第二人民医院眼科,河南郑州450003 [2]中国医学科学院北京协和医学院肿瘤医院麻醉科,北京100021

出　　处：《中国卫生检验杂志》2017年第24期3581-3582,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的观察强直性脊柱炎(AS)患者并发葡萄膜炎的人类白细胞抗原B27(HLA-B27)阳性率及临床特点,以提高对强直性脊柱炎相关的葡萄膜炎的认识水平,减少误诊或漏诊率。方法对32例临床确诊为葡萄膜炎的强直性脊柱炎患者行HLA-B27、视力、裂隙灯、眼底等检查。结果强直性脊柱炎并发葡萄膜炎的患者HLA-B27阳性28例,阳性率为87.5%。强直性脊柱炎并发葡萄膜炎的患者平均发病年龄为(27.6±12.5)岁,其中男性26例,女性6例。强直性脊柱炎并发葡萄膜炎的患者双眼发病者4例,单眼发病者28例,以前部葡萄膜炎反应的29例,全葡萄膜炎反应的3例。结论HLA-B2的患者多为HLA-B27阳性的青年男性,多以单眼发病,葡萄膜炎以前葡萄膜炎反应为主。Objective To investigate HLA-B27 positive rate and the clinical characteristics of ankylosing spondylitis（ AS） patients complicated with uveitis,in order to improve the understanding of ankylosing spondylitis associated uveitis level,reduce the misdiagnosis or missed diagnosis. Methods 32 patients with ankylosing spondylitis were conducted for the examination of HLA-B27,vision,slit lamps and fundus. Results In patients with ankylosing spondylitis and uveitis,28 patients were HLA-B27-positive,with a positive rate of 87. 5%. The mean age at onset of ankylosing spondylitis with uveitis was（ 27. 6 ± 12. 5） years old,including 26 males and 6 females. Ankylosing spondylitis with uveitis were detected in 4 patients with binocular onset,in 28 patients with monocular disease,previous uveitis reaction was detected in 29 patinets,and uveitis in 3 patients. Conclusion Most of AS patients complicated with uveitis are HLA-B27 positive and young males,which is often characterized by anterior uveitis and single eye disease. HLA-B2 patients are mostly HLA-B27-positive young men,mostly with monocular disease,and previous uveitis is prior in uveitis.

关 键 词：HLA-B27 强直性脊柱炎 葡萄膜炎 

分 类 号：R773[医药卫生—眼科]