卡介苗联合透明质酸灌注治疗膀胱肿瘤疗效分析  

Curative effect analysis of BCG combined with hyaluronic acid perfusion in treatment of bladder tumor

作　　者：孙航[1] 余良[1] 张惠敏[1] 蒋少华[1] 孙文[1] 周春辉[1] 吕晓辉[1] 

机构地区：[1]解放军第三医院泌尿外科,陕西宝鸡721000

出　　处：《西北国防医学杂志》2017年第12期796-798,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探讨卡介苗(BCG)联合透明质酸(HA)灌注治疗膀胱肿瘤的疗效。方法:选取2012-03~2015-03非肌层浸润性膀胱肿瘤(NMIBC)患者62例,随机分为实验组(n=33)和对照组(n=29)。经尿道膀胱肿瘤切除(TURBT)术后1周开始按疗程行BCG 100mg灌注,排空膀胱后,实验组灌注40 mg HA/50ml生理盐水,对照组灌注50 ml生理盐水。分别于灌注3、6个月时记录患者膀胱过度活动症自我评价量表评分(OABSS)和膀胱疼痛视觉模拟评分(VAS),膀胱镜检查肿瘤复发情况。结果:灌注治疗3个月时实验组OABSS评分低于对照组,但差异无统计学意义(P>0.05),VAS评分低于对照组(P<0.05),且两组均无肿瘤复发病例。灌注治疗6个月时,实验组OABSS评分和VAS评分以及与灌注前评分的差值均显著低于对照组(均P<0.01),两组分别有7例和6例肿瘤复发,复发率无显著性差异(P>0.05)。结论:HA灌注能够减轻BCG引起的局部症状,且不增加肿瘤复发率,可作为NMIBC患者可耐受的膀胱灌注新疗法。Objective： To investigate the therapeutic efficiency of bacille calmetteguerin （BCG） combined with hyaluronic acid （HA） perfusion in treatment of blaclder tumor.Methods： Sixty--two patients with non muscle invasive bladder cancer （NMIBC） were randomly divided into experimental group （n ：33） and control group （n=29）.All the patients were received BCG perfusion 100 mg after transurethral resection of bladder tumor （TURBT） one week.The experimental group was given 40 mg HA/50 ml saline, while the control group were given 50 ml saline. Overactive bladder symptom score （OABSS） and visual analogue scale （VAS） score were recorded 3 and 6 months postoperative.Results： After perfusion 3 month,the OABSS score of experimental group was lower than that in control group, but the difference was not significant （P〉0.05）, however, the VAS score was significantly lower （P〈0.05）. No recurrences were found in both groups. After perfusion 6 month, the OABSS and VAS scores and differentials between these two scores before preperfusion were both significantly lower in experimental group than those in the control group （P 〈 0. 01）. There were seven recurrent cases in the experimental group and six cases in the control group, the differences were not statistically significant （P 〉 0.05）. Conclusion ： HA perfusion can reduce the symptoms caused by BCG,and the recurrence rate is controlled.The combination of BCG and HA may become a new perfusion therapeutic method for NMIBC patients after TURBT.

关 键 词：膀胱肿瘤 透明质酸 卡介苗 膀胱过度活动症 膀胱疼痛综合征 

分 类 号：R737.14[医药卫生—肿瘤]