艾司西酞普兰辅助治疗儿童神经性厌食症伴哮喘的临床疗效及安全性研究  

Clinical efficacy and safety of escitalopram in the treatment of pediatric anorexia nervosa complicated with asthma

作　　者：牟银莲 陈一[2] 贺会利 赵秀莲 

机构地区：[1]陕西省西安市阎良区人民医院儿科,西安710089 [2]陕西省西安市儿童医院,西安710043

出　　处：《广西医科大学学报》2017年第12期1765-1768,共4页Journal of Guangxi Medical University

摘　　要：目的:探讨艾司西酞普兰辅助治疗儿童神经性厌食症(AN)伴哮喘的临床疗效及安全性。方法:将62例AN伴哮喘患儿分为观察组和对照组,每组31例。对照组给予常规治疗,观察组在常规治疗的基础上给予艾司西酞普兰辅助治疗。比较两组临床疗效、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分及AN症状评分,并观察肺功能指标及体重指数(Ibm)变化。结果:观察组治疗总有效率为93.55%,显著高于对照组的77.42%(P<0.05)。治疗后,观察组第1秒用力呼气容积(FEV1)、FEV1占用力肺活量(FVC)百分比和最大呼气流速(PEF)均显著高于对照组,HAMA、HAMD和AN症状评分显著低于对照组(P<0.05);随访3个月,观察组的Ibm增长幅度显著高于对照组(P<0.05)。结论:艾司西酞普兰辅助治疗儿童AN伴哮喘安全、有效,可改善患儿负性情绪,改善AN症状和肺功能,促进患儿体重增长。Objective： To investigate the clinical efficacy and safety of escitalopram in the treatment of pediatric anorexia nervosa（AN）complicated with asthma. Methods： 62 AN children with asthma were divided into a control group and an observation group,with 31 cases in each group. The children in the control group received conventional therapy,and those in the observation group were treated as the control group with addition of escitalopram. The clinical efficacy,Hamilton anxiety scale（HAMA）score,Hamilton depression scale（HAMD）score,and AN symptom score were compared. Lung function and body mass index were observed as well. Results： The total response rate in the observation group was 93. 55%,which was significantly higher than that in the control group（77. 42%）（P〈0. 05）. After treatment,the forced expiratory volume in 1 second（FEV1）,the ratio of FEV1 to forced vital capacity（FVC）and the peak expiratory flow（PEF）in the observation group were significantly higher than those in the control group,while the scores of HAMA,HAMD and AN symptoms were significantly lower（P〈0. 05）. Aftera follow-up of 3 months,a significant increase in body mass index was noted in the observation group,compared with the control group（P〈0. 05）. Conclusion： Escosipramine was safe and effective for the treatement of pediatric AN complicated with asthma. It could improve children＇s negative emotions,AN symptoms and lung function,and promote weight gain.

关 键 词：神经性厌食症 哮喘 艾司西酞普兰 疗效 安全性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]