肝硬化1号汤加减联合腹水超滤回输对肝肾综合征患者微炎症状态及肝肾功能保护的影响  

Effect of Liver Cirrhosis 1 Decoction Combined with Ascites Ultrafiltration Reinfusion on the Micro Inflammatory State and the Protection of Liver and Kidney Function in Patients with Hepatorenal Syndrome

作　　者：曹玉鹃[1] 柴梅[1] 姚耀[1] 李沧友 

机构地区：[1]沧州市传染病医院,河北沧州061000

出　　处：《四川中医》2018年第1期119-121,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：河北省中医药局2017年课题项目

摘　　要：目的:观察自拟中药联合腹水超滤回输对肝肾综合征患者微炎症状态及肝肾功能的保护的影响。方法:选择2016年3月~2017年9月我院肝病科收住的肝肾综合征患者120例,采用随机数字表法将患者分为三组,即A组采用腹水超滤法治疗,B组采用肝硬化1号汤加减治疗,C组采用肝硬化1号汤加减联合腹水超滤法治疗。然后对比三组临床疗效;检测并对比两组24小时尿蛋白、β_2-MG、Scr、BUN、ALB等生化指标以及IL-6、hs-CRP、TNF-α等微炎症指标;对比三组肝功能Child-Pugh分级情况。结果:A组、B组总有效率对比,无统计学差异(P>0.05);C组总有效率为97.5%显著高于A组、B组(P<0.05);治疗后A组Scr、BUN水平显著降低(P<0.05);B组、C组24小时尿蛋白、β_2-MG、Scr、BUN水平显著降低,ALB水平显著升高,且C组最为显著(P<0.05);治疗后B组、C组IL-6、hs-CRP、TNF-α均显著降低,且C组最为显著(P<0.05);治疗后A组Child pugh分级情况显著优于B组、C组(P<0.05)。结论:肝肾综合征患者采用肝硬化1号汤加减联合腹水超滤回输治疗能够有效改善肝肾功能,控制微炎症组状态,预后效果显著。Objective： To investigate the effect of Chinese herbal medicine combined with ascites uhrafihration reinfusion on the micro inflammatory state and the protection of liver and kidney function in patients with hepatorenal syndrome. Methods： 120cases of hepatorenal syndrome were collected from the department of gastroenterology in our hospital from March 2016to September-2017. The patients were divided into three groups by the random number table method, group A was treated with ascites uhrafihration, group B was treated with Liver Cirrhosis 1 Decoction, group C was treated with Liver Cirrhosis 1 Decoction com- bined with ascites uhra_fihration. Then compared the clinical efficacy of the three groups, detected and compared the two groups of 24h urinary protein, β2-MG, Set, BUN, ALB and other biochemical indicators. And IL-6, hs-CRP, TNF-alpha and other micro inflammatory indexes ; Child-Pugh grading of liver function was compared between the three groups. Results ： There was no significant difference between the A group and the B group （ P 〉 0. 05 ） ; The total effective rate in the C group was 97.5% , significantly higher than that in the A group and the B group （P〈0. 05） ; After treatment, the levels of Scr and BUN were significantly lower in A group （P〈0. 05） ; the levels of 24h urinary protein, β2-MG, Ser and BUN in group B and group C were significantly lower, and the level of ALB increased significantly, and the C group was the most significant （P〈0. 05 ） ; After treatment, group B, group C, IL-6, hs-CRP, TNF-alpha were significantly lower, and the C group was most significant （ P〈0. 05 ） ; After treatment, the Child and Pugh classification in the A group were significantly better than those in the B group and the C group （P〈0. 05）. Conclusion： Patients with hepatorenal syndrome treated with cirrhosis ldecoetion combined with ascites ultrafiltration reinfusion can effectively improve the function of liver and kidney, and control the state of micro inflammatory grou

关 键 词：肝肾综合征 腹水超滤浓缩治疗 中医中药 疗效 

分 类 号：R575[医药卫生—消化系统]