肿块型与非肿块型乳腺癌ADC值、Ki67指数的对比分析  

Comparative analysis of ADC value and Ki67 index in mass-like and non-mass-like breast cancer

作　　者：李芹[1] 牛庆亮[1] 杜汉旺[1] 郑召龙 朱亚宁[1] 

机构地区：[1]潍坊市中医院医学影像中心,山东潍坊261041

出　　处：《中国临床医学影像杂志》2018年第1期11-13,27,共4页Journal of China Clinic Medical Imaging

摘　　要：目的 :探讨肿块型与非肿块型乳腺癌ADC值、Ki67的表达情况,比较两者之间的差异及相关性。方法 :选取2014年9月—2016年12月我院收治的91例非特殊型乳腺癌患者作为研究对象,所有患者在手术或穿刺前均行常规MRI、动态增强及弥散加权成像,术后标本行常规病理及免疫组化检查并获得Ki67指数,分别比较肿块型与非肿块型乳腺癌ADC值、Ki67的差异性,并分析两组病例ADC值与Ki67指数的关系。结果:肿块型乳腺癌(60/91)与非肿块型乳腺癌(31/91)Ki67指数分别为(32.42±14.943)%、(25.81±10.416)%,两者之间差异性显著(t=2.200,P<0.05);肿块型与非肿块型乳腺癌ADC值分别为(0.575±0.215)×10^(-3)mm^2/s和(1.14±0.718)×10^(-3) mm^2/s,两者差异具有统计学意义(t=-4.280,P<0.05)。在非肿块型乳腺癌中,浸润性癌较导管原位癌ADC值更低,两者差异性显著(P<0.05)。无论在非肿块型还是肿块型乳腺癌,其ADC值与Ki67之间均无显著相关性(P>0.05)。结论:与非肿块型乳腺癌相比,肿块型乳腺癌表现出更高的Ki67指数和更低的ADC值;非肿块型乳腺癌中浸润性乳腺癌具有低ADC值;但在肿块型与非肿块型乳腺癌中ADC值与Ki67均无显著相关性。Objective： To investigate the differences and correlations of Ki67 expression and ADC value in mass-like and non-mass-like breast cancer. Methods： Ninety-one patients with non-specific type breast cancer in our hospital from Septem- ber 2014 to December 2016 were analyzed retrospectively. All the subjects undertook MRI examination （plain scan, DWI and DCE-MRI） before operation or biopsy. Routine pathological examination and the expression of Ki67 were detected by im- munohistochemical method on specimens. The differences of Ki67 expression and ADC value were compared between mass- like and non-mass-like breast cancer groups, and correlations between Ki67 expression and ADC value were analyzed in two groups respectively. Results： The expression of Ki67 was （32.42±14.943）% and （25.81±10.416）% in mass-like breast cancer group（60/91） and non-mass-like breast cancer group（31/91）, and significant difference was observed between the two groups（t= 2.200, P〈0.05）. ADC value was （0.575±0.215）x10-3mm2/s and （1.14±0.718）10-3 mmZ/s in mass-fike breast cancer group and non-mass-like breast cancer group with significant difference （t=-4.280, P〈0.05）. In non-mass-like breast cancer, the ADC value was lower in invasive cancer than DCIS（P〈0.05）. No relationship was found between the expression of Ki67 or ADC val- ue in either group （P〉0.05）. Conclusion： Compared with non-mass-like breast cancer, mass-like breast cancer shows higher Ki67 expression level and lower ADC value. In non-mass-like relationship was found between the expression of Ki67 or ADC breast cancer, invasive breast cancer has lower ADC value. No value in either mass-like or non-mass-like breast cancer.

关 键 词：乳腺肿瘤 磁共振成像 弥散 

分 类 号：R737.9[医药卫生—肿瘤]