TGF-β在下颌髁突软骨的发育和改建中作用研究进展  

Research progress of effects of TGF-β on the development,growth remodeling and degradation of mandibular condylar cartilage

作　　者：何东萍 罗应伟[1] 

机构地区：[1]昆明医科大学附属口腔医院,云南昆明650031

出　　处：《口腔医学》2018年第1期78-82,共5页Stomatology

基　　金：云南省科技厅-昆明医科大学应用基础研究联合资金项目(2015FB043)

摘　　要：转化生长因子β(transforming growth factor beta,TGF-β)是一种多功能的细胞因子,广泛参与细胞的多种生物学过程,如细胞增殖分化、胞外基质的合成和组织修复等。近年来的研究发现,髁突软骨的发育必须有TGF-β的参与,TGF-β可介导局部的功能刺激作用,参与髁突软骨的适应性改建,与髁突软骨退行性病变相关。本文就TGF-β在髁突软骨发育、改建和退行性关节病中的作用作一综述。Transforming growth factorq3 （TGF-β） is a muhifunctional cytokine, which performs many crucial cellular functions in cell biological processes such as cell proliferation and differentiation, extracellular matrix synthesis and tissue repair. Recent studies have shown that TGF-β plays an important role in the development of the mandibular condylar cartilage. It mediates local functional stimulus in the remodeling of condylar cartilage and has a potential role in the development of TMJ osteoarthritis, protecting the articular carti- lage. The purpose of this review is to discuss effects of TGF-β on the development, remodeling growth and degradation process of man- dibular condylar cartilage.

关 键 词：转化生长因子Β 下颌骨髁状突 骨发育 骨关节炎 

分 类 号：R782.6[医药卫生—口腔医学]