手术与手术联合放化疗对70例喉癌患者的临床效果比较  

Comparison of the Clinical Effect of Surgery and Surgery Combined with Radiotherapy and Chemotherapy for 70 Patients with Laryngeal Cancer

作　　者：李燕[1] 朱力[1] 罗伟[1] 文科[1] 吴定江 

机构地区：[1]成都医学院第一附属医院,610500

出　　处：《实用癌症杂志》2018年第2期236-239,共4页The Practical Journal of Cancer

摘　　要：目的分析研究经手术与手术联合放化疗治疗70例喉癌患者中的临床效果比较及远期并发症。方法选取喉癌患者70例,随机分成对照组和观察组2组,各35例,对照组仅行手术切除,试验组行手术+放化疗治疗,分析比较2组的临床效果及远期并发症情况。结果观察组35例喉癌患者中Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者术后5年生存率分别为90.91%、61.54%、44.44%、0,与对照组(83.33%、58.33%、44.44%、0)相比无显著性差异,临床总有效率远远高于对照组,差异具有统计学意义(P<0.05),且观察组5年总生存率(60.00%)与对照组(62.86%)较接近,P>0.05。观察组复发转移总发生率为34.28%,与对照组(37.14%)相比无统计学差异,P>0.05。观察组术后2例喉腔狭窄、3例肺部感染、3切口感染、2例皮下气肿、1例第二原发恶性肿瘤(食管癌),对照组术后2例喉腔狭窄、4例肺部感染、2切口感染、3例皮下气肿、2例第二原发恶性肿瘤(食管癌),两组对比无统计学差异,P>0.05。观察组术后的总满意度(74.28%)与对照组(77.14%)接近,不存在统计学差异(P>0.05)。结论针对于喉癌患者,采用手术疗法与手术联合放化疗治疗的术后生存率、复发转移情况无明显差异,两种方式的并发症并无显著不同,但针对不同患者可采取相应放化疗进行延缓病情发展,本研究对临床上研究喉癌治疗具有参考价值。Objective To evaluate the clinical efficacy and long-term complications of 70 patients with laryngeal carcinoma treated by surgery and surgery combined with radiotherapy and chemotherapy. Methods 60 patients with laryngeal cancer were randomly divided into the control group and the observation group （ n = 35）. The control group was treated with surgical re- section. The patients were treated with chemotherapy and chemotherapy. The clinical effects and long-term complications were ana- lyzed. Results The 5-year survival rates of patients with stage Ⅰ, Ⅱ, Ⅲ and Ⅳ laryngeal cancer were 90.91% ,61.54% and 44.44% ,0% respectively,and of the control group were 83.33% ,58.33% ,44.44% ,0% （P 〈 0.05 ）, and the 5-year overall survival rate of the observation group（60.00% ） and that of the control group （ 62.86% ） was similar（ P 〉 0.05 ）, the total recur- rence rate of the observation group was 34.28%, which was not statistically different from that of the control group,37.14% （P 〉 0.05）. In the observation group,there had 2 cases of laryngeal stenosis,3 cases of pulmonary infection,3 cases of incision infec- tion ,2 cases of subcutaneous emphysema, 1 case of primary malignant tumor （esophageal cancer） ,in the control group, there had 2 cases of laryngeal stenosis ,4 cases of lung Department of infection ,2 cases of incision infection ,3 cases of subcutaneous emphy- sema,2 cases of second primary malignant tumor （ esophageal cancer）, the 2 groups had no significant difference, P 〉 0.05. The total satisfaction （74.28%） in the observation group was close to that of the control group （77.14%） ,and there was no statistical difference （ P 〉 0.05 ）. Conclusion There has no significant difference in the survival rate and recurrence between operation and operation combined with radiotherapy and chemotherapy for laryngeal cancer. There has no significant difference in complica- tions between the 2 methods, but the corresponding radiotherapy and chemotherapy delay the deve

关 键 词：手术联合放化疗 喉癌 生存率 并发症 

分 类 号：R739.65[医药卫生—肿瘤]