进口碘化油TACE联合洛铂治疗晚期肝癌肺转移的临床疗效观察  

Efficacy of Inward Iodized Oil TACE Combined with Lobaplatin for Primary Liver Cancer with Lung Metastasis

作　　者：李科[1] 孔轶[1] 

机构地区：[1]湖南省肿瘤医院,410000

出　　处：《实用癌症杂志》2018年第2期244-246,共3页The Practical Journal of Cancer

摘　　要：目的观察进口碘化油肝动脉化疗栓塞(TACE)联合洛铂治疗晚期肝癌肺转移的治疗效果。方法将88例原发性肝癌肺转移患者随机分为对照组和观察组,每组44例。对照组采取替吉奥胶囊和复方苦参注射液治疗。观察组采取进口碘化油TACE联合洛铂治疗。比较两组血清甲胎蛋白(AFP)和癌胚抗原(CEA)水平、临床症状评分、近期疗效及不良反应。结果治疗后1个月,两组患者血清中AFP和CEA水平及临床症状评分明显减少(P<0.01),但两组间比较无显著性差异(P>0.05)。观察组近期总缓解率为22.73%,对照组为20.45%,两组比较无显著性差异(P>0.05)。两组患者不良反应发生率比较无显著性差异(P>0.05)。结论进口碘化油TACE联合洛铂是治疗晚期肝癌肺转移的一种有效方法。Objective To observe efficacy of inward iodized oil transcatheter arterial chemoembolization （TACE） com- bined with Lobaplatin for primary liver cancer with lung metastasis. Methods 88 patients with primary liver cancer and lung metastasis were randomly divided into the control group and the observation group, with 44 cases in each group. The control group was given with Tegafur gimeracil oteracil potassium capsule and compound Kushen injection. The observation group was treated with inward iodized oil TACE combined with Lobaplatin. Serum levels of AFP and CEA, symptoms, clinical efficacy, and toxic and side effect were compared between both groups. Results After one month treatment, serum levels of AFP and CEA and scores of symptoms were obviously decreased in both groups（ P 〈 0.01 ）, and no statistical significance between the 2 groups（ P 〉 0.05 ）. Total remission rate of the observation group was 22.73%, the control groups was 20.45% , and there had no statistical significance between the 2 groups （ P 〉 0.05 ）. Occurrence rates of toxic and side effect had no statistical significance between the 2 groups （ P 〉 0.05 ）. Conclusion Inward iodized oil TACE combined with Lobaplatin is an effective therapy method in the treatment of primary liver cancer with lung metastasis.

关 键 词：碘化油 洛铂 原发性肝癌 肺转移 肝动脉化疗栓塞 

分 类 号：R735.7[医药卫生—肿瘤]