丙泊酚单次给药及持续小剂量给药在无痛内镜治疗中的安全性比较  

Comparison of the safety of single propofol and continuous small dose in painless endoscopic treatment

作　　者：张丽华[1] 李美鹚 陈虹君[1] 张江平[2] 

机构地区：[1]中山大学附属第五医院消化内镜中心,广东省珠海市519000 [2]中山大学附属第五医院呼吸内科,广东省珠海市519000

出　　处：《临床合理用药杂志》2018年第2期10-11,16,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察丙泊酚单次给药及持续小剂量给药在无痛内镜治疗中的安全性比较。方法将医院接受无痛内镜检查的患者147例随机分为观察组(74例)和对照组(73例),观察组给予持续小剂量丙泊酚注射液麻醉,对照组给予丙泊酚注射液单次足量麻醉。观察2组患者在无痛内镜治疗中的安全性并监测其生命体征,统计2组患者临床舒适度评价及不良反应发生情况。结果 2组麻醉后3 min各项数值较麻醉前均下降(P均<0.01),但2组心率(HR)、呼吸(RR)、收缩压(SBP)、舒张压(DBP)水平比较无明显差异(P>0.05),观察组血氧饱和度(Sp O2)水平高于对照组(P<0.01)。观察组不良反应发生率为17.57%,低于对照组的35.62%(P<0.01);观察组舒适度评分高于对照组,差异有统计学意义(P<0.05)。结论在无痛内镜麻醉中,持续小剂量丙泊酚给药可减轻患者低氧血症发生率,同时降低不良反应发生率,提高舒适度,值得临床推广应用。Objective To observe the safety of single full dose and continuous small-dose in painless endoscopy treatment. Methods 147 patients who underwent painless endoscopy in our hospital were randomly divided into observation group（ 74 cases） and control group（ 73 cases）. The observation group was given continuous small-dose propofol injection to anesthesia,the control group to inject sufficient anesthesia. The safety of painless endoscopy in both groups was observed and their vital signs were monitored. The clinical comfort evaluation and adverse reactions of the two groups were statistically analyzed. Results After anesthesia 3 min,the indexes of vital signs in both groups declined（ P 0. 01）. While,the heart rate（ HR）,respiration rate（ RR）,systolic blood pressure（ SBP） and diastolic blood pressure（ DBP） in the two groups showed no significant difference（ P 0. 05）. The level of Sp O2 in observation group was higher than that in control group（ P 0. 01）. The incidence of adverse reactions in the observation group was 17. 57%,which was lower than 35. 62% of the control group（ P 0. 01）.The comfort score of the observation group was higher than that of the control group,and the difference was statistically significant（ P 0. 05）. Conclusion Continuous small-dose could reduce the patient hypoxemia incidence while reducing adverse reaction rate and improve comfort. It worths the clinical application.

关 键 词：丙泊酚 单次给药 持续小剂量给药 无痛内镜术 安全性 

分 类 号：R57[医药卫生—消化系统]