人类白细胞抗原G在肾移植术后尿路上皮癌中表达情况的初步研究  

A preliminary study on the expression of human leucocyte antigen G in urothelial carcinoma after renal transplantation

作　　者：徐磊 方祺[2] 王海峰[1] 杨占坡[1] 王伟[1] 刘光明[1] 姚世杰[1] 马洪顺[1] 

机构地区：[1]天津市第一中心医院泌尿外科,300192 [2]天津市第一中心医院生殖医学科,300192

出　　处：《中华泌尿外科杂志》2018年第1期49-53,共5页Chinese Journal of Urology

基　　金：天津市卫生局科技基金（2013KZ029）

摘　　要：目的探讨人类白细胞抗原G（HLA-G）在肾移植术后尿路上皮癌中的表达情况及其与肾移植术后尿路上皮癌发生的关系。 方法选取2005年1月至2016年6月我院29例肾移植术后尿路上皮癌（RTUC）患者肿瘤标本为RUTC组，年龄（55.5±8.1）岁，范围32～70岁；29例同期非移植术后尿路上皮癌（NTUC）患者肿瘤标本为NTUC组，年龄（57.9±8.2）岁，范围36～74岁；15例经膀胱镜活检术后病理证实的正常尿路上皮组织（NUTE）标本为NUTE组，年龄（58.3±8.2）岁，范围44～71岁。所有患者均为首次发病。采用免疫组化染色法检测3组样本中HLA-G的表达差异，并结合RTUC患者临床病理资料进行分析。 结果HLA-G在RTUC组、NTUC组和NUTE组中的表达率分别为79.3%（23/32）、37.9%（11/32）和0（0/15），NTUC组与NUTE组相比，差异有统计学意义（P〈0.05），RTUC组与NUTE组相比，差异有统计学意义（P〈0.05），RTUC组与NTUC组相比，差异有统计学意义（P〈0.05）。 结论HLA-G的表达与RTUC的发生发展相关，HLA-G可以为RTUC的预防及治疗提供一个新思路。ObjectiveTo investigate the expression of human leucocyte antigen G （HLA-G） in urothelial carcinoma after renal transplantation, and to analyse the relationship between HLA-G expression and the various clinical and pathological parameters. Methods29 patients with urothelium carcinoma after renal transplantation for the first time from January 2005 to June 2016 were selected as the experimental group, the age range was 32-70 years, with an average of （55.5±8.1）years. 29 non-transplanted patients with urothelial carcinoma as the control group 1, the age range was 36-74 years, with an average of （57.9±8.2）years. 15 cases of normal urinary tract epithelial were from cystoscopy biopsy as the control group 2. Immunohistochemical method was used to detect the difference of HLA-G expression between the three groups. The clinical and pathological data of patients with urothelial carcinoma after renal transplantation were analyzed. ResultsThe expression rate of HLA-G was 79.3% （23/32） in patients with urothelial carcinoma after renal transplantation, 37.9% （11/32） in non-transplanted group and 0 （0/15） in normal urinary tract epithelium group. The expression rate of HLA-G in non-transplanted group was significantly higher than that in normal urinary tract epithelium group （P〈0.05）. The expression rate of HLA-G in patients with urothelial carcinoma after renal transplantation was significantly higher than that in non-transplanted group and normal urinary tract epithelium group （P〈0.05）. ConclusionsHLA-G is associated with the occurrence of urothelial carcinoma after renal transplantation. It may provide a new idea for the prevention and treatment of urinary tract epithelium after renal transplantation.

关 键 词：人类白细胞抗原G 肾移植 尿路上皮癌 移植后恶性肿瘤 

分 类 号：R737.1[医药卫生—肿瘤]