银杏叶提取物联合视听觉综合训练对帕金森患者血浆一氧化氮、氧化应激指标水平和运动能力的影响  

Effect of Ginkgo Biloba Extract Combined with Comprehensive Audiovisual Training on Plasma Nitric Oxide, Oxidative Stress and Exercise Capacity in Patients with Parkinson＇s Disease

作　　者：周莉[1] 江华[1] 沈流燕 曾国利[1] 余倩[1] 邓楠[1] 

机构地区：[1]四川省泸州市人民医院神经内科,四川泸州646000

出　　处：《医学临床研究》2018年第1期15-18,共4页Journal of Clinical Research

摘　　要：【目的】观察银杏叶提取物联合视听觉综合训练对帕金森（PD）患者血浆一氧化氮（NO）、氧化应激指标水平和运动能力的影响。【方法】选取2014年5月至2016年5月本院神经内科收治的60例原发性PD患者为研究对象，随机分为观察组和对照组各30例，对照组患者给予银杏叶提取物注射液，观察组在对照纽基础上联合进行综合视听觉训练，治疗3个月后观察比较两组患者血清中血管活性物质含量[NO、内皮素（ET）]、氧化应激指标[超氧化物歧化酶（SOD）、谷胱甘肽过氧化酶（GSH—Px）、丙二醛（MDA）]、运动能力[帕金森评定量表中运动检查评定部分（UPDRSIII）、Berg平衡量表积分]及治疗期间不良反应发生情况。【结果】治疗后两组患者NO、ET、SOD、MDA和GSH—Px指标均较治疗前显著改变，且观察纽患者NO、SOD和GSH—Px指标显著高于对照组（P〈0．05），而ET、MDA指标显著低于对照组（P〈0．05）。与对照组相比，治疗后观察组患者UPDRSUI积分显著降低，而Berg平衡量表积分显著升高，差异具有统计学意义（P〈0．05）。治疗期间两组患者不良反应发生率比较不具有统计学意义（P〉0．05）。【结论】银杏叶提取物联合视听觉综合训练能够显著改善患者机体氧化应激水平，提高患者运动功能，且不良反应发生率低，值得临床推广应用。[Objective]To observe the effect of Ginkgo biloba extract combined with comprehensive visual and auditory training on the levels of plasma nitric oxide （NO）, reduction of oxidative stress and capacity of exercise in patients with Parkinson＇s disease （PD）. [Methods]A total of 60 patients with primary PD admitted to the Department of Neurology in the hospital during May 2014 to May 2016 were enrolled in the study. The patients were evenly divided into the observation group and the control group using a random number table, with 30 cases in each group. Patients in the control group weregiven Ginkgo biloba extract injectionswhile patients in the observation group were given visual and auditory combined training on the basis of Ginkgo biloba extract injections. After 3 months of treatment, the levels of serum vasoactive substances [（NO, endothelin lET）], indices of oxidative stress [superoxide dismutase （SOD）, glutathione peroxidase （GSH-Px）, malondialdehyde （MDA）], scores on the Unified Parkinson＇s Disease Rating Scale （UPDRS） Part HI （UPDRS [U ）, scores on the Berg balance, and rates of adverse reactions during treatment were compared between the two groups. [Results]After treatment, NO, ET, SOD, MDA and GSH-Px changed significantly. NO, SOD and GSH-Px were significantly higher in the observation group than the control group （ P 〈0.05） while ET and MDA were significantly lower than the control group （ P 〈0.05）. After treatment, the UPDRS III score of the observation group was significantly lower and the Berg balance score was significantly higher than those of the control group （ P 〈0.05）. After treatment, the walk test time was significantly shorter in the observation group than the control group, and 6 minutes walking distance, stride length and walking speed were significantly higher in the observation group than the control group （ P〈0.05）. There was no significant change of frequency in the two groups before and after treatment （ P 〉0.05）. There

关 键 词：银杏 植物提取物/药理学 声刺激 光刺激 帕金森病 一氧化氮 氧化性应激 运动试验 

分 类 号：R742.5[医药卫生—神经病学与精神病学]