改良短程放疗治疗结直肠癌对患者病理降期及耐受性的影响  

Observation on Pathological Down-staging and the Tolerance of Patients with Colorectal Cancer Treated by Modified Short-course Radiotherapy

作　　者：王武峰 彭少华 李有强 

机构地区：[1]海南省农垦总医院放疗科,海南海口570311

出　　处：《医学临床研究》2018年第1期68-69,72,共3页Journal of Clinical Research

摘　　要：【目的】探讨改良短程放疗治疗结直肠癌对患者病理降期及耐受性的影响。【方法】将本院74例结直肠癌患者随机分为观察组与对照组，两组患者均采取新辅助放化疗干预，观察组行改良短程放疗，对照组常规放疗，比较两组术后3个月临床分期变化，记录住院时间及花费情况，并对放疗相关不良反应进行比较评价。【结果】两组患者干预后分期较干预前均呈显著降低趋势，且差异有显著性（P〈0．05）；观察组干预后病理分期与对照组比较差异无显著性（P〉0．05）；观察组住院时间、放化疗费用及住院其他费用均低于对照组，且差异有显著性（P〈0．05）；两组骨髓抑制、放射性皮炎、放射性肠炎发生率及程度分级比较差异均无显著性（P〉0．05）。【结论】改良短程放疗与常规放疗的近期降期率基本相当，且前者未见放疗相关不良反应发生率升高，但可缩短住院时间，降低患者经济负担，值得临床推广应用。[Objective]To explore the effect of modified short course radiotherapy on pathological stage and patient tolerance in the treatment of eolorectal cancer. [Methods] Seventy-four patients with coloreetal cancer in our hospital were randomized into the observation group and the control group. Both groups were treated with neoadjuvant radiotherapy and chemotherapy, but the observation group was treated with modified short-course radiotherapy and the control group was treated with routine radiotherapy. Changes of clinical staging were compared between the two groups in 3 months postop- erativly. Length of hospital stay and costs were recorded, and the radiotherapy related adverse reactions were evaluated to assess the patient＇s tolerance. [Results] There was a significant decrease in the staging of the two groups of patients after radiotherapy, and the difference was significant compared with that before the intervention （ P 〈0.05）. However, there were no significant differences between the two groups （ P 〉0.05）; Length of hospital stay, costs of radiotherapy and chemotherapy, and other expenses in the observation group were significantly lower than those in control group （ P 〈0.05） ; There were no significant differences in the incidence rate and grade of bone marrow suppression, radiation dermatitis and radiation enteritis between the two groups （ P 〉0.05）. [Conclusion ]The short-term down-staging rate and curative effects of modified short-course radiotherapy are similar to those of routine radiotherapy, and does not increase the incidence rates of adverse reactions induced by radiotherapy. It can shorten the length of hospital stay, and reduce financial burden of patients. It has high clinical application value.

关 键 词：结直肠肿瘤/放射疗法 结直肠肿瘤/病理学 肿瘤分期 辐射耐受性 

分 类 号：R735.37[医药卫生—肿瘤]