普萘洛尔对婴幼儿增殖期血管瘤患儿血VEGF及CXCL12、CXCR4水平影响  

Effect of propranolol on levels of serum VEGF,CXCL12,CXCR4 in infants with hemangioma at proliferative phase

作　　者：李立佳 吴新来 郑诗华 符梅竹[1] 黄惠敏 谢海清[1] 张晓钿[3] 

机构地区：[1]海南医学院第一附属医院,海南海口570102 [2]海南省肿瘤医院,海南海口570312 [3]海南医学院,海南海口571199

出　　处：《现代中西医结合杂志》2018年第5期462-464,472,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：海南省卫生计生行业科研项目(16A200012);海南省高等学校科学研究项目(Hnky2017-33)

摘　　要：目的观察普萘洛尔治疗方案对婴幼儿增殖期血管瘤患儿血清CXCL12、CXCR4及血管内皮生长因子(VEGF)水平的影响。方法将50例婴幼儿增殖期血管瘤患儿作为观察组,以50例同期健康体检的婴幼儿作为对照组。观察组给予普萘洛尔口服(3个月以下0.5 mg/kg,3~6个月1 mg/kg,6个月以上2 mg/kg,2次/d,以4~6个月为1个疗程)。记录对照组与观察组治疗前及治疗4周、12周静脉血CXCL12、CXCR4与VEGF水平,以超声测量观察组治疗前及治疗12周后肿瘤体积并进行疗效评价。结果观察组治疗12周后血管瘤体积明显减小(P<0.05),疗效优良率为62.0%。观察组治疗前的VEGF及CXCL12、CXCR4水平与对照组比较明显升高(P均<0.05),治疗4周与12周后均比治疗前明显降低(P均<0.05)。结论普萘洛尔治疗增殖期血管瘤患儿效果较好,其机制可能与抑制血管上皮细胞增殖相关。Objective It is to observe the effect of the treatment with propranolol on the levels of serum CXCL12, CXCR4 and vascular endothelial growth factor （VEGF） in the infants with hemangioma at proliferative phase. Methods 50 infants with hemangioma at proliferative phase were selected as observation group and were treated with propranolol by oral administration （0.5 mg/kg for 3 months old, 1 mg/kg for 3 to 6 months old, 2 mg/kg for 〉 6 months old, 2 times/d, 4 - 6 months as one treatment course）. 50 healthy infants were selected as control group. The levels of CXCL12, CXCR4 and VEGF in venous blood in the control group, before treatment and after treatment for 4 weeks, 12 weeks in the observation group were detected, and the tumor volume was evaluated before and after treatment with ultrasonic measurement and the curative effect was evaluated in the observation group. Results After treatment, the volume of hemangioma was significantly reduced in the observation group （P 〈 0.05） , and the effective rate was 62.0%. Compared with the control group, the levels of VEGF, CXCL12 and CXCR4 were significantly higher in the observation group before treatment （P 〈 0.05 ） , but the levels of these indexes were significantly reduced after treatment for 4 and 12 weeks （P 〈 0.05 ）. Conclusion Propranolol is effective in the treatment for proliferative hemangioma in infants, and its mechanism may be associated with inhibition of proliferation of vascular epithelial cells.

关 键 词：普萘洛尔 婴幼儿 增殖期血管瘤 血管内皮生长因子 CXCL12 CXCR4 

分 类 号：R732.2[医药卫生—肿瘤]