急慢性胰腺炎免疫反应的研究进展  

The immune response in acute and chronic pancreatitis

作　　者：屈琳林[1] 易湘 孙红玉[1] 黄竹[1] 汤礼军[1] QU Lin-lin;YI Xiang;SUN Hong-yu;HUANG Zhu;TANG Li-jun(General Surgery Center of PLA, Chengdu Military General Hospital, Key Laboratory of Pancreas Injury and Repair in Sichuan Province, Chengdu 610083, China;Department of Information Management, 60 Hospital of PLA, Dali, Yunnan 671003, China)

机构地区：[1]成都军区总医院全军普外中心、胰腺损伤与修复四川省重点实验室,成都610083 [2]解放军60医院,云南大理671003

出　　处：《解放军医学杂志》2018年第1期75-78,共4页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金面上项目(81772001);国家临床重点专科项目(41732113)~~

摘　　要：急慢性胰腺炎是常见的消化系统疾病。近年来免疫细胞和炎性因子在急慢性胰腺炎发病机制中的作用受到越来越多的关注。最新研究表明,巨噬细胞、高迁移率族蛋白1(HMGB1)和白细胞介素-33(IL-33)等在胰腺炎的病理进程中发挥着重要作用,并受到多级调控。免疫细胞不但具有感应微环境的能力,还可对内源和外源分子的危险信号做出反应,在胰腺炎的发生和演进中发挥重要作用。对胰腺炎免疫调控机制的深入解读,有望为其有效治疗策略的建立提供新的思路和潜在靶标。本文就急慢性胰腺炎相关免疫反应的研究进展作一综述。Acute and chronic pancreatitis are most common gastrointestinal diseases. Recently, there are emerging evidences that immune cell play important roles in the pathogenesis of acute and chronic pancreatitis. Studies have shown that macrophages, high mobility group protein 1（HMGB1） and interleukin-33（IL-33） play an important role in the pathological process of pancreatitis, and are regulated by multiple levels. For example, immune cells are critical in the development and progression of pancreatitis, which not only have the ability to induce microenvironment, but also respond to danger signals derived from endogenous and exogenous molecules. Therefore, further understanding of relevant immune signaling will provide new idea and potential therapeutic targets that can prevent disease progression. Here, we review recent data from animal and human clinical studies that focus on immune responses.

关 键 词：急性胰腺炎 慢性胰腺炎 巨噬细胞 高迁移率族蛋白1 白细胞介素-33 

分 类 号：R576[医药卫生—消化系统]