芎归六君子汤对实验性大鼠冠心病的治疗作用  

Ameliorating effect of Xionggui Liujunzi Decoction on coronary heart disease in rats

作　　者：郑丽莉[1] 

机构地区：[1]山东协和学院,济南250109

出　　处：《中国比较医学杂志》2018年第1期23-27,55,共6页Chinese Journal of Comparative Medicine

基　　金：山东省中医药管理局科技计划项目(编号:2015-312);山东省高等学校科技计划项目(编号:J16LK56)

摘　　要：目的探讨芎归六君子汤对实验性冠心病的效果。方法将大鼠随机分为空白对照组、模型对照组、西药对照组(辛伐他丁)、中药对照组(复方丹参滴丸)和芎归六君子汤组。采用脂肪乳剂灌胃法和垂体后叶素诱发冠脉痉挛法复制冠脉硬化急性心肌缺血双模型。检测心电图ST段、血脂改变,炎症因子肿瘤坏死因子TNF-α、白介素IL-6、白介素IL-10、高敏反应蛋白hs-CRP、单核细胞趋化蛋白MCP-1、细胞间黏附因子ICAM-1,血管内皮活性物质ET-1、NO、TXA2、PGI2,纤溶系统血浆PAI-1、t-PA含量。结果各给药组心电图ST段、血脂、炎症因子、血管内皮活性物质和纤溶系统较模型对照组改善,差异有显著性(P<0.05),且芎归六君子汤组改善效果优于中药和辛伐他丁组(P<0.05)。结论芎归六君子汤能改善冠心病模型的心电图、血脂、血管内皮和纤溶功能,减轻炎症反应,对大鼠冠脉硬化和心肌缺血有显著效果。Objective To explore the effect of a Chinese Medicine Xionggui Liujunzi Decoction on the experimental coronary heart disease in rats. Methods Rats were randomly divided into five groups： the blank control group,the model control group,the western medicine control group（ simvastatin）,the Chinese medicine control group（ compound Danshen dripping pills） and the Xionggui Liujunzi Decoction group. The coronary heart disease was induced by intragastric gavage of fat emulsion（ 10 m L/kg,q. d. for 12 weeks） and pituitrin（ 30 U/kg,q. d. for 3 days） was intraperitoneally injected to induce coronary artery spasm. Changes of the ST segment in electrocardiogram（ ECG） and the blood lipids were detected,and the levels of the inflammatory factors including tumor necrosis factor-α（ TNF-α）,interleukin-6（ IL-6）,interleukin-10（ IL-10）,highly sensitive C-reactive protein（ hs-CRP）,monocyte chemotactic protein-1（ MCP-1） and intercellular adhesion molecule-1（ ICAM-1）,the vascular endothelial active substances including ET-1,NO,TXA2 and PGI2,and the indicators of fibrinolytic system function such as PAI-1,t-PA in the plasma were measured. Results Compared with the model control group,each drug treatment showed better effects on the ST segment of the electrocardiogram,blood lipids,levels of the inflammatory factors and vascular endothelial active substances,and the fibrinolytic function, with significant differences（ P〈0. 05）. In particular, Xionggui Liujunzi Decoction has a significantly better effect than the compound Danshen dripping pills and simvastatin（ P〈0. 05）. Conclusions Xionggui Liujunzi Decoction can improve the ST segment of the electrocardiogram,blood lipids,levels of the vascular endothelialactive substances and fibrinolytic function of the rat model of coronary heart disease,and alleviate inflammation responses,showing a significant effect on coronary arteriosclerosis and myocardial ischemia in rats.

关 键 词：脾胃 芎归六君子汤 冠心病 冠脉硬化 大鼠 

分 类 号：R-33[医药卫生]