运动神经元病患者脑脊液及血清碱性成纤维细胞生长因子2与临床关系的研究  

Relationship of CSF and serum FGF-2 level with clinical parameters in motor neuron disease patients

作　　者：拱忠影[1] 高丽娜[1] 郭洁[1] 卢轶[1] 臧大维[1] 

机构地区：[1]天津市第一中心医院神经内科,300192

出　　处：《中华老年心脑血管病杂志》2018年第1期55-59,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：天津市卫生局科技基金(11KG104;2015KZ035;2015KZ022)

摘　　要：目的探讨运动神经元病(MND)患者脑脊液及血清碱性成纤维细胞生长因子2(FGF-2)水平变化及其与临床指标的关系。方法选择MND患者91例(MND组),其中肌萎缩侧索硬化症(ALS)患者70例,进行性肌肉萎缩(PMA)患者9例,进行性延髓麻痹(PBP)患者7例,原发性侧索硬化(PLS)患者5例。采用酶联免疫吸附法检测MND患者血清及脑脊液FGF-2水平,另选择同期非炎症性神经系统疾病患者40例为对照组。采用改良版肌萎缩侧索硬化功能量表评估ALS患者神经功能缺损程度,疾病进展率评估患者疾病进展水平,同时随访ALS患者的生存时间。结果 MND组ALS、PMA、PLS患者血清FGF-2水平明显高于对照组(P<0.01)。MND组ALS患者脑脊液FGF-2水平明显高于对照组[(319.2±105.9)ng/L vs(241.7±34.3)ng/L,P<0.01]。ALS患者血清和脑脊液FGF-2与疾病病程呈正相关,与疾病进展率呈负相关(P<0.01)。MND患者的生存分析结果提示,累积生存率PMA>PLS>ALS>PBP,差异有统计学意义(P=0.000)。高FGF-2水平ALS患者累积生存率明显高于低FGF-2水平患者(P=0.002)。结论血清和脑脊液FGF-2水平在部分MND患者中增高,其可能是疾病分型及评估疾病进展、预测生存的生物学标志物之一。Objective To study the relationship of CSF and serum FGF-2 level with clinical parameters in MND patients.Methods Ninety-one MND patients served as a MND group and 40 noninflammtory nervous system disease patients served as a control group.Their CSF and serum FGF-2 level were measured by ELISA.The neurological deficit in ALS patients was assessed according to the modified ALSFRS-r,the progression of MND was assessed according to the DPR.The ALS patients were followed up,during which their survival time was recorded.Results The serum FGF-2 level was significantly higher in MND group than in control group（P〈0.01）.The CSF,FGF-2 level were significantly higher in ALS patients of MND group than in those of control group（319.2±105.9 ng/L vs 241.7±34.3 ng/L,P〈0.01）.The CSF and serum FGF-2 level were positively correlated with the duration of MND and negatively correlated with the DRP in ALS patients（P〈0.01）.Survival analysis of MND patients indicated that the survival time of PMA patients was longer than that of PLS,ALS and PBP patients（P=0.000）.The cumulative survival rate of ALS patients with a high serum FGF-2 level was significantly higher than that of those with a low serum FGF-2 level（P=0.002）.Conclusion The CSF and serum FGF-2 level are higher in some MND patients and can be used as one of the biomarkers for evaluating the progression and predicting surrival.

关 键 词：运动神经元病 脑脊髓液 成纤维细胞生长因子2 

分 类 号：R744.8[医药卫生—神经病学与精神病学]