老年卵巢癌患者血清CA125、HE4及ROMA指数变化的价值研究  

Study on the value of serum CA125,HE4 and ROMA index in elderly patients with ovarian cancer

作　　者：王艳君[1] 杜秀娟[1] 

机构地区：[1]宝鸡市中心医院妇科,陕西宝鸡721008

出　　处：《海南医学院学报》2018年第2期213-215,219,共4页Journal of Hainan Medical University

基　　金：陕西省自然基金研究计划(2016JM8110)~~

摘　　要：目的:研究老年卵巢癌患者血清肿瘤标志物糖类抗原125(CA125)、人附睾分泌蛋白4(HE4)及卵巢癌恶性风险模型(ROMA)指数变化的价值,为临床诊断提供选择方案。方法:选取我院2015年12月~2017年12月收治的110例卵巢癌患者作为恶性组,另选取同期收治的120例卵巢良性肿瘤患者作为良性组,选取来院参加健康体检的92例健康女性作为对照组。3组均采用微粒子酶免疫化学发光法检测血清中HE4、CA125水平及阳性率,并分析ROMA指数值联合评估卵巢癌风险性。结果:3组相比,恶性组患者的血清CA125、HE4水平及ROMA指数均明显高于良性组及对照组(P<0.05),良性组CA125水平高于对照组(P<0.05),但良性组HE4水平及ROMA指数与对照组相比差异无统计学意义(P>0.05)。阳性率对比,恶性组患者血清CA125、HE4水平及ROMA指数阳性率分别为76.4%、92.7%、96.4%,高于良性组的28.3%、18.3%、15.0%,差异均有统计学意义(P<0.05)。诊断效能相比,CA125的阴性预测值、阳性预测值、特异性、敏感度均低于HE4,联合计算的ROMA指数的阴性预测值、阳性预测值、特异性、敏感度高于单一诊断。结论:老年卵巢癌患者血清CA125、HE4水平及ROMA指数均明显高于老年卵巢良性肿瘤患者及健康女性,且联合诊断阳性率最高,具有高敏感性及高特异性,可在临床上推广。Objective:To study the value of serum tumor markers,carbohydrate antigen 125(CA125),human epididymis secretory protein 4(HE4)and ovarian cancer risk factor(ROMA)index in elderly patients with ovarian cancer,so as to provide a choice for clinical diagnosis.Methods:A total of 110 cases of ovarian cancer treated in our hospital in December-2017 December 2015 were selected as malignant group.In addition,120 cases of benign ovarian tumors in the same period were selected as the benign group,and 92 healthy women who came to the hospital for health examination were selected as the control group.The three groups were detected by microparticle enzyme immunochemiluminescence assay in serum HE4,CA125 levels and positive rates,and ROMA index values were combined to assess the risk of ovarian cancer.Results:Three groups of patients in malignant group serum CA125,HE4 level and ROMA index were significantly higher than those in the benign group and the control group(P<0.05),the level of CA125 positive group was higher than control group(P<0.05),but the level of HE4 and ROMA index in benign group compared with the control group,the difference was not statistically significant(P>0.05).Compared with the positive rate,the positive rates of serum CA125,HE4 and ROMA index in malignant group were 76.4%,92.7%,96.4%,which were higher than those in benign group(28.3%,18.3%,15%),and the difference was statistically significant(P<0.05).Compared with the diagnostic efficiency,the negative predictive value,positive predictive value,specificity and sensitivity of CA125 were all lower than those of HE4.The negative predictive value,positive predictive value,specificity and sensitivity of the combined ROMA index were higher than those of single diagnosis.Conclusion:serum CA125,HE4 and ROMA index in elderly patients with ovarian cancer are significantly higher than those in elderly patients with benign ovarian tumors and healthy women.The combined diagnosis is the highest,with Gao Min's high sensitivity and specificity,which can be popularized i

关 键 词：老年卵巢癌 糖类抗原125 人附睾分泌蛋白4 卵巢癌恶性风险模型 

分 类 号：R737.31[医药卫生—肿瘤]