老年“双抗”患者的胃黏膜损害及其保护策略  

Gastric Mucosal Damage Induced by Dual Anti-platelet Therapy and its Prevention in Elderly

作　　者：张倩倩 郑松柏 

机构地区：[1]复旦大学附属华东医院消化科,200040

出　　处：《胃肠病学》2018年第1期3-7,共5页Chinese Journal of Gastroenterology

摘　　要：由于老年心脑血管病患者日益增多,应用双联抗血小板治疗(简称"双抗")的老年人也越来越多,从而使"双抗"引起的胃黏膜损害成为常见的临床问题,"双抗"患者的胃黏膜保护已成为多学科关注的热点。老年人胃黏膜屏障退化,其所承受的损伤或侵袭因素更多、更重,故"双抗"导致的胃黏膜损害也更常见、危害更大,其胃黏膜保护策略也与中青年患者有所不同。本文就上述内容作简要综述。With the increase of elderly patients with cardiovascular and cerebrovascular diseases,dual anti-platelet therapy（ DAPT） is becoming more and more commonly used in the elderly,and at the same time gastric mucosal damage induced by DAPT has become a common issue in clinical practice. Therefore,prevention of gastric mucosal injury induced by DAPT in elderly has turned to be a research hot-spot. Because of the degeneration of gastric mucosal barrier,the injury and invasive factors endured by the elderly were more severe and prominent,and gastric mucosal damage induced by DAPT will be more frequent and severe. Therefore,the gastric mucosal protective strategies for elderly with DAPT should be different from that of young and middle-aged patients. In this article,the gastric mucosal damage induced by DAPT and its protective strategies in elderly were briefly reviewed.

关 键 词：老年人 胃黏膜屏障 阿司匹林 血小板聚集抑制剂 质子泵抑制剂 

分 类 号：R57[医药卫生—消化系统]