胃癌家族史与慢性胃炎幽门螺杆菌感染和胃黏膜病理变化的关系  

Correlation of Family History of Gastric Cancer With Helicobacter pylori Infection and Pathological Changes of Gastric Mucosa in Patients With Chronic Gastritis

作　　者：朱婷婷[1] 张荣秋 窦迎春[1] 周长宏[1] 

机构地区：[1]青岛大学附属青岛市市立医院东院干部保健科,266071

出　　处：《胃肠病学》2018年第1期42-44,共3页Chinese Journal of Gastroenterology

摘　　要：背景:胃癌家族史是胃癌遗传易感性的重要标志,研究显示胃癌家族史对慢性胃炎患者的幽门螺杆菌(Hp)感染和临床病理表现可能有一定影响。目的:探讨慢性胃炎患者胃癌家族史与Hp感染和胃黏膜病理变化的关系。方法:选取312例慢性胃炎患者,评估胃癌家族史与Hp感染、胃黏膜炎症程度、炎症活动性、萎缩和肠化生程度的关系。结果:312例慢性胃炎患者中有胃癌家族史者165例(52.9%),无胃癌家族史者147例(47.1%),有胃癌家族史者Hp感染率、胃黏膜萎缩、肠化生程度均显著高于无胃癌家族史者(P<0.05),但两组间胃黏膜炎症程度、炎症活动性差异无统计学意义(P>0.05)。结论:有胃癌家族史的慢性胃炎患者Hp感染率较高,并可加重胃黏膜萎缩和肠化生。Background： Family history of gastric cancer is an important indicator of genetic susceptibility. Studies have shown that the family history of gastric cancer might have impact on Helicobacter pylori（ Hp） infection and clinicopathological manifestations in patients with chronic gastritis. Aims： To investigate the correlation of family history of gastric cancer with Hp infection and pathological changes of gastric mucosa in patients with chronic gastritis. Methods： A total of 312 patients with chronic gastritis were enrolled to study the relationship between family history of gastric cancer and Hp infection,degree of gastric mucosal inflammation,activity of inflammation,and degree of atrophy and intestinal metaplasia. Results：In the 312 patients with chronic gastritis,165（ 52. 9%） had family history of gastric cancer,and 147（ 47. 1%） without family history of gastric cancer. Incidence of Hp infection,degree of gastric mucosal atrophy and intestinal metaplasia in patients with family history of gastric cancer were significantly higher than those without（ P 0. 05）,but no significant differences in degree and activity of inflammation were found between the two groups（ P 0. 05）. Conclusions： The incidence of Hp infection is higher in chronic gastritis patients with family history of gastric cancer. Family history of gastric cancer may aggravate gastric mucosal atrophy and intestinal metaplasia.

关 键 词：胃肿瘤 家族史 幽门螺杆菌 胃黏膜 炎症 萎缩 化生 

分 类 号：R573.3[医药卫生—消化系统] R735.2[医药卫生—内科学]