比较节拍化疗与常规化疗治疗老年晚期结直肠癌的疗效及安全性的差异  

Comparison of the Efficacy and Safety of Beating Chemotherapy with Conventional Chemotherapy in the Maintenance of Advanced Colorectal Cancer in Elderly Patients

作　　者：闫帅[1] 茅卫东[1] 林峰 沈冬[1] 刘少平[1] 钱文军[1] 吕叶[1] 林青凤[1] 苏筠 

机构地区：[1]东南大学医学院附属江阴市人民医院肿瘤科,江苏江阴214400

出　　处：《中外医疗》2017年第33期117-119,共3页China & Foreign Medical Treatment

摘　　要：目的探析老年晚期结直肠癌患者采用常规化疗与节拍化疗治疗的效果。方法方便选取2012年1月—2017年7月该院收治的老年晚期结直肠癌的患者50例作为研究对象,随机分成参照组(常规化疗:FOLFOX4方案、FOLFIRI方案)24例与干预组(希罗达节拍化疗联合奥沙利铂化疗)26例,比较两组疗效及不良反应发生的情况。结果干预组有效率(CR+PR)为46.2%,对照组有效率为45.8%,两者差异无统计学意义(P>0.05)。但节拍化疗不良反应发生情况和副反应严重程度优于参照组,老年肿瘤患者耐受性好。结论老年晚期结直肠癌患者采用希罗达节拍化疗联合奥沙利铂化疗治疗的效果不劣于FOLFOX4和FOLFIRI方案常规化疗。Objective This paper tries to investigate the effect of conventional chemotherapy, maintenance therapy and beat chemotherapy on advanced colorectal cancer in the elderly. Methods 50 elderly patients with advanced colorectal cancer from January 2012 to July 2017 in this hospital were convenient selected as the research objects and randomly divided into the control group（conventional chemotherapy： FOLFOX4 regimen, FOLFIRI regimen, 24 cases） and the intervention group（metronomic chemotherapy of xeloda combined with oxaliplatin chemotherapy, 26 cases）, and the curative effect and the adverse reactions were compared between the two groups. Results In the intervention group, the efficiency（CR ＋PR） was46.2%, the control group was 45.8%, with no difference between them（P 〉0.05）. But the side effects of metronomic chemotherapy and severity of adverse reactions were better than the reference group, elderly cancer patients were well tolerated. Conclusion Elderly patients with colorectal cancer with Xeloda beat chemotherapy combined with oxaliplatin chemotherapy is not inferior to FOLFOX4 and FOLFIRI regimen conventional chemotherapy.

关 键 词：结直肠癌 常规化疗 节拍化疗 

分 类 号：R73[医药卫生—肿瘤]