CDC25A与CDK1在胃癌组织中的表达及其临床意义  

The Expression and the Clinical Significance of CDC25A and CDK1 in Gastric Cancer

作　　者：傅华[1] 于爱军[1] 陈凯 张学军[1] 李巍[1] 

机构地区：[1]承德医学院附属医院外一科,河北承德067000

出　　处：《河北医学》2018年第1期80-83,共4页Hebei Medicine

基　　金：承德市科技支撑计划项目;(编号:20142044)

摘　　要：目的:探索CDC25A和CDK1在胃癌组织中的表达及其临床意义。方法:应用免疫组化的方法检测119例胃癌组织中CDC25A和CDK1的表达情况,通过统计分析CDC25A和CDK1与胃癌患者的临床病理特征之间的关系。结果:CDC25A和CDK1在高分化胃癌组织低表达,在低分化胃癌组织中高表达,与胃癌的病理分级具有相关性(P<0.001);CDC25A和CDK1在早期胃癌中低表达,在晚期胃癌组织中高表达,与胃癌TNM分期具有相关性(P<0.01);CDC25A和CDK1的表达与胃癌患者有淋巴结转移(P<0.001)相关,CDC25A和CDK1在发生淋巴结转移的胃癌组织中高表达,在未发生淋巴结转移的胃癌组织中低表达。结论:CDC25A与CDK1有望成为胃癌诊断与治疗的潜在的分子标志。Objective： To investigate the expression and the clinical significance of CDC25 A and CDK1 in gastric carcinoma. Methods： Immunohistochemistry was used to detect the expression of CDC25 A and CDK1 in gastric cancer tissue of 119 cases. The correlation of the expression CDC25 A and CDK1 and clinical pathological characteristics were analyzed. Results： The expression of CDC25 A and CDK1 in highly differentiated gastric cancer tissues was highly expressed in low differentiated gastric cancer tissues,and had significant correlation with the pathological grade of gastric cancer（ P〈0.001）. CDC25 A and CDK1 were low expression in early gastric cancer,high expression in advanced gastric cancer tissue and significant correlation with TNM staging of gastric cancer（ P〈0. 01）. The expression of CDC25 A and CDK1 is significantly associated with lymph node metastasis（ P〈0.001） in patients with gastric cancer. CDC25 A and CDK1 are highly expressed in gastric carcinoma with lymph node metastasis,and low expression in gastric cancer tissues without lymph node metastasis（ P〈0.001）. Conclusion： CDC25 and CDK1 could be potential biomarker for diagnosis and treatment of gastric cancer.

关 键 词：CDC25A CDK1 胃癌 转移 分子标志 

分 类 号：R735.2[医药卫生—肿瘤]