美常安与阿司匹林对结直肠高危腺瘤行内镜切除术后复发的影响  

Effects of Medilac-s and Aspirin on Recurrence of High-Risk Colorectal Adenomas after Endoscopic Resection

作　　者：刘东林[1] 王爱瑶[1] 左邦祺 姜春桂 胡坚方[1] 曾俊[1] 王小琼[1] 孟君[1] 

机构地区：[1]江西省人民医院消化内科,南昌330006 [2]江西共青城市人民医院内科,江西共青城332020 [3]江西共青城市人民医院药剂科,江西共青城332020

出　　处：《实用临床医学（江西）》2017年第12期7-10,共4页Practical Clinical Medicine

基　　金：江西省卫生厅普通科技计划(20143008)

摘　　要：目的探讨美常安与阿司匹林对结直肠高危腺瘤行内镜切除术后复发的影响。方法将102例行内镜切除术后的结直肠高危腺瘤患者按随机数字表法分为3组:治疗1组34例,采用拜阿司匹林肠溶片100 mg口服,1次·d-1;治疗2组34例,采用枯草杆菌二联活菌肠溶胶囊(商品名:美常安)0.5g口服,3次·d-1;2组疗程均为2年。对照组34例,不使用任何药物。观察3组结直肠腺瘤复发率及治疗1组、治疗2组不良反应发生率。结果治疗1组结直肠腺瘤复发率与治疗2组比较差异无统计学意义(9.68%比12.90%,P>0.05)。治疗1组、治疗2组结直肠腺瘤复发率均明显低于对照组(40.63%)(均P<0.05)。治疗1组不良反应发生率与治疗2组比较差异无统计学意义(12.90%比9.68%,P>0.05)。结论口服阿司匹林与美常安均能够降低结直肠高危腺瘤行内镜切除术后的复发率,且安全性较好。Objective To explore the effects of Medilac-s and aspirin on the recurrence of highrisk colorectal adenomas after endoscopic resection.Methods A total of 102 patients who underwent endoscopic resection for high-risk colorectal adenomas were randomly divided into three groups,with 34 patients in each group.The first therapy group was treated with Bayaspirin tablets 100 mg once per day for 2 years,and the second therapy group with combined Bacillus subtilis and Enterococcus faecium enteric capsules(Medilac-s)0.5 g three times per day for 2 years.The control group received no medication.The recurrence rate of colorectal adenomas and incidence of adverse reactions were observed in all the three groups.Results There were no significant differences between the first and second therapy groups with colorectal adenomas in recurrence rate(9.68% vs 12.90%)and incidence of adverse reactions(12.90% vs 9.68%)(P>0.05).However,the recurrence rate of colorectal adenomas in therapy groups was obviously lower than that in control group(40.63%)(P<0.05).Conclusion Both aspirin and Medilac-s can safely reduce the recurrence rate of high-risk colorectal adenomas after endoscopic resection.

关 键 词：枯草杆菌二联活菌肠溶胶囊 阿司匹林 结直肠高危腺瘤 内镜切除术 术后 复发 

分 类 号：R735.3[医药卫生—肿瘤] R656[医药卫生—临床医学]