CAF同步卡培他滨再程放疗治疗直肠癌术后复发的疗效及对免疫功能的影响  

Effect of CAF synchronized capecitabine combined with radiotherapy on postoperative recurrence of rectal cancer and its influence on immune cells

作　　者：钟轩[1] 王红钰 郑宝军 王爱军 冯俊伟 

机构地区：[1]河北省唐山市开滦总医院普外科,063000 [2]河北省唐山市工人医院肿瘤外科,063000

出　　处：《检验医学与临床》2018年第3期336-338,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨加速超分割(CAF)同步卡培他滨再程放疗治疗直肠癌术后复发的疗效及对免疫功能的影响。方法选取2014年5月至2016年9月在河北省唐山市开滦总医院行直肠癌术后复发患者71例。所有患者应用CAF同步卡培他滨再程放疗治疗,CAF 1.2Gy/f,每日2次,每次间隔6h,卡培他滨850ms/m2,每日2次,口服。放疗结束后化疗2个疗程。结果 71例患者中有2例患者因重度腹泻停止化疗,退出研究。69例患者中完全缓解11例(15.94%),部分缓解42例(60.87%),病情稳定12例(17.39%),病变进展4例(5.80%),临床总有效率为76.81%。患者1年生存率为84.06%,局部控制率为59.64%;2年生存率为62.32%,局部控制率为42.64%。患者经过再次化疗后T淋巴细胞水平与化疗前比较,差异无统计学意义(P>0.05)。69例患者出现肝功能损伤2例(2.90%)、肾功能损伤1例(1.49%)、消化道反应21例(30.43%)、周围神经炎8例(11.59%)。所有不良反应均小于Ⅳ级,均可耐受。结论 CAF同步卡培他滨再程放疗治疗直肠癌术后复发可提高局部控制率、延长生存期,对T淋巴细胞水平影响较小,不良反应轻,安全性较好。Objective To investigate the effect of accelerated fractionation(CAF)and capecitabine on postoperative recurrence of rectal cancer and its influence on immune cells.Methods From May 2014 to September 2016,71 patients with recurrent rectal cancer in Kailuan General Hospital of Hebei,Tangshan City province were selected.All patients were treated with CAF synchronous capecitabine and radiotherapy,using CAF,1.2 Gy/F,two times a day,each interval of 6 h,capecitabine 850 ms/m2,once a day,oral two times.Two cycles of chemotherapy after radiotherapy.Results Totally 71 cases of patients with severe diarrhea stopped chemotherapy,withdrew from the study.And 69 cases of patients with complete remission in 11 cases(15.94%)and partial in 42 cases(60.87%),12 cases(17.39%)in a stable condition,the lesion progress in 4 cases(5.80%),the clinical total effective rate was 76.81%.The 1-year survival rate was 84.03% and the local control rate was 59.64%.The 2-year survival rate was 62.32% and the local control rate was 42.64%.There was no significant difference between T lymphocyte and chemotherapy before and after chemotherapy in the study(P>0.05).This study 69 patients of liver injury in 2 cases(2.90%),renal damage in 1 case(1.49%),gastrointestinal tract reaction,21 cases(30.43%),peripheral neuritis,8 cases(11.59%).All adverse reactions were less than gradeⅣ,which could be tolerated.Conclusion Accelerated fractionation and capecitabine after radiotherapy for rectal cancer can improve the local control rate,prolong the survival time,and have little influence on the level of T lymphocyte.The toxicity is mild and the safety is better.

关 键 词：加速超分割 卡培他滨 直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]