IL-10基因多态性与膀胱癌风险关联的病例对照研究  

A Case-control Atudy of Interleukin-10 Gene Polymorphism and the Risk of Bladder Cancer

作　　者：陈昆[1] 韩前河[1] 单中杰[1] 

机构地区：[1]郑州人民医院泌尿外科,河南省郑州市450003

出　　处：《医学理论与实践》2018年第2期172-173,共2页The Journal of Medical Theory and Practice

摘　　要：目的:探讨IL-10基因启动子区-592A/C单核苷酸多态性与膀胱癌易感性的关系。方法:采用病例-对照研究方法,以PCR-RFLP技术分别检测膀胱癌患者和健康对照的IL-10基因启动子区-592A/C单核苷酸多态,比较不同基因型与膀胱癌风险的关联。结果:IL-10基因启动子区-592各基因型及等位基因在两组之间的分布有显著差异,与AA基因型相比,携带CA、CC基因型的个体患膀胱癌的风险显著增加。结论:IL-10基因启动子区-592A/C突变与个体患膀胱癌的风险显著相关,该位点SNP检测可作为膀胱癌分子标志物。Objective:To study the association between genetic polymorphism of interleukin-10(IL-10)gene promoter-592A/C and the risk of bladder cancer.Methods:A hospital-based case-control study was used in this study.-592A/C single nucleotide polymorphisms in IL-10 promoter region of bladder cancer patients and healthy controls were detected by PCR-RFLP,and the association of different genotypes with bladder cancer risk was compared.Results:The genotype distribution and allele frequency of-592A/C gene had significant differences between patient group and control group.Compared to the individual carrying AA genotype,the risk of bladder cancer with CA genotype and CC genotype increased.Conclusion:IL-10-592A/C gene polymorphism may be a risk factor for bladder cancer and it may serve a molecular marker for detecting bladder cancer.

关 键 词：膀胱癌 IL-10 多态性 易感性 

分 类 号：R737.14[医药卫生—肿瘤]