右归胶囊治疗绝经后女性下肢动脉粥样硬化的临床疗效观察  

Clinical Effect of Yougui Capsule on Lower Extremity Atherosclerotic Disease in Postmenopausal Women

作　　者：孙璐[1] 陈基敏[1] 陈咸川[1] 吴晨[1] 谢吟灵[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院老年科,上海200437

出　　处：《老年医学与保健》2018年第1期37-40,共4页Geriatrics & Health Care

摘　　要：目的观察右归胶囊治疗绝经后女性下肢动脉粥样硬化性疾病(lower extremity atherosclerotic disease,LEAD)的临床疗效。方法将64例绝经后LEAD女性患者随机分为观察组(n=32)和试验组(n=32)。年龄60~95岁,平均(72.8±10.5)岁。观察组患者在一般治疗的基础上,口服西洛他唑胶囊,50 mg,2次/d;试验组在观察组的基础上,口服右归胶囊,1.8 g,3次/d。所有患者连续治疗12周,并在治疗前后分别检测E2和ABI,评价中医证候积分。结果治疗前2组ABI差异无统计学意义,治疗后观察组ABI未见改善,试验组ABI治疗前后差异有统计学意义[(0.52±0.06)vs(0.73±0.08),P<0.05],且治疗后试验组ABI优于观察组[(0.73±0.08)vs(0.57±0.07),P<0.05]。治疗前所有患者E2均<20 pg/mL,治疗后试验组E2升高,且改善优于观察组(84.34%vs 0%,P<0.01)。治疗后试验组总有效率优于观察组(87.5%vs 43.8%,P<0.01)。结论右归胶囊能够改善绝经后女性的E2水平,升高ABI,改善LEAD的中医证候。Objective To observe the clinical effect o f Yougui capsule on lower extremity atherosclerotic disease （LEAD） in postmenopausal women. Methods 64 postmenopausal women, aged from 60 to 95 with the average of （72.8 ± 1 0 .5 ） years, were randomly divided into 2 groups： observation group and experiment group, 32 in each; general treatment plus oral administration of cilostazol capsules （50 mg once, twice a day） was performed on all the patients in both groups while oral administration of Yougui capsules （1.8 g once, 3 times a day） was added to patients in experiment group; the courses in the 2 groups both lasted for 12 weeks; the detections of estradiol （E2） and ankle brachial index （ABI） were made before and after treatment respectively and TCM syndrome scores were evaluated. Results Before treatment, there existed no statistical difference in ABI between the 2 groups; after treatment, no improvement in ABI in observation group; ABI in experiment group after treatment was statistically different from that before treatment [（0.52±0.06） vs （0 .7 3 ± 0 .0 8 ）,P〈 0 .0 5 ] and was superior to that in observation group [（0.73 ±0.08） ra （0.57±0.07）, P〈0.05]; before treatment, E2 of all the patients in both groups were under 20 pg/mL while, after treatment, E2 of the patients in experiment group increased and was superior to that of the paitents in observation group （84.34% vs 0%, P 〈 0 .0 1 ） ; after treatment, the total effective rate in experiment group was higher than that in observation group （87.5% 43.8%, P〈0.01）. Conclusions Yougui capsules can increase thelevel of E2 in postmenopausal women, raise ABI and improve the TCM syndrome scores of LEAD.

关 键 词：绝经后期 动脉粥样硬化 踝臂指数 雌二醇 右归丸 

分 类 号：R259[医药卫生—中西医结合]