肝再生磷酸酶3在恶性血液病中的研究进展  

Advances of phosphatase of regenerating liver-3 in hematological malignancies

作　　者：刘凤琪 徐丽梅 李娟[1] 王海河[2] 童秀珍[1] LIU Feng-qi;XU Li-mei;LI Juan;WANG Hai-he;TONG Xiu-zhen(Department of Hematology,The First Affiliated Hospital,Sun Yat-sen University,Department of Biochemistry,Zhongshan School of Medicine,Sun Yat-sen Universit)

机构地区：[1]中山大学附属第一医院血液科,广东广州510080 [2]中山大学中山医学院生化系,广东广州510080

出　　处：《中国病理生理杂志》2018年第2期375-379,共5页Chinese Journal of Pathophysiology

基　　金：广东省自然科学基金资助项目(No.2015A030313090);广东省科技计划项目(No.2017A020215105)

摘　　要：肝再生磷酸酶3（phosphatase of regenerating liver-3,PRL-3）是蛋白酪氨酸磷酸酶家族的一员。蛋白酪氨酸磷酸酶家族有107个成员,它们通过将底物去磷酸化从而参与某些信号通路,被认为在肿瘤的发生和发展过程中发挥了一定的作用。2001年,Saha等[1]通过基因表达系列分析（serial analysis of gene expression,SAGE）的方法发现,In recent years,accumulating evidence shows that phosphatase of regenerating liver-3（ PRL-3） is closely implicated in tumor progression,especially in the stages of invasion and metastasis of various solid tumors,including colorectal cancer,gastric cancer and breast cancer. However,the study of PRL-3 in hematological malignancies is relatively lagged,but there are some advances in leukemia and myeloma,in which PRL-3 up-regulation is tightly associated with poor prognosis,while the underlying mechanism of signal transduction is gradually explored. In this review,we summarized the recent advances of PRL-3 in hematological malignancies such as acute myeloid leukemia,multiple myeloma and chronic myeloid leukemia,as well as the molecular mechanism of PRL-3 in pathogenesis.

关 键 词：肝再生磷酸酶3 急性髓系白血病 多发性骨髓瘤 慢性粒细胞白血病 

分 类 号：R0[医药卫生] R363