74例结核分枝杆菌耐药情况分析  

Analysis of drug resistance in 74 cases of mycobacterium tuberculosis

作　　者：兰萍[1] 刘梅[2] 李娜娜[2] 王建华[2] 陈玲[2] 

机构地区：[1]遵义医学院珠海校区,广东珠海519041 [2]遵义医学院附属医院呼吸医学研究室,贵州遵义563003

出　　处：《中国现代医生》2018年第1期130-132,共3页China Modern Doctor

基　　金：贵州省科学技术基金项目(黔科合J字[2012]2354号)

摘　　要：目的了解遵义地区结核分枝杆菌耐药情况,并探讨其耐药特点,为耐药结核病的监测提供参考。方法采用比例法对我院门诊及住院的肺结核患者痰标本中分离到的74株结核分枝杆菌进行异烟肼、利福平、链霉素和乙胺丁醇4种一线抗结核药物的敏感性试验。结果 74例肺结核患者结核分枝杆菌对一线抗结核药的总耐药率为54.1%,耐多药率为12.2%。结论本地区结核分枝杆菌耐药情况严重,应进一步加强耐药结核的监测。Objective To understand the drug resistance of mycobacterium tuberculosis in Zunyi and explore the char- acteristics of its drug resistance, so as to provide a reference for the surveillance of drug-resistant tuberculosis. Meth- ods 74 strains of mycobacterium tuberculosis isolated from sputum samples of outpatients and inpatients in our hospital were given sensitivity test of 4 kinds of first-line anti-TB drugs, including isoniazid, rifampicin, streptomycin and ethambutol. Results The total drug resistance rate of mycobacterium tuberculosis to first-line anti-tuberculosis drugs in 74 patients with pulmonary tuberculosis was 54.1%, and multi drug resistance rate was 12.2%. Conclusion The drug resistance of mycobacterium tuberculosis in this area is serious, and the surveillance of drug-resistant TB should be further strengthened.

关 键 词：结核分枝杆菌 药物敏感试验 耐药率 监测 

分 类 号：R446.5[医药卫生—诊断学]