阿尔兹海默病与帕金森病共性病理机制研究进展  

Common Pathological Mechanism of Alzheimer’s Disease and Parkinson’s Disease

作　　者：沈杨 张琦 赵佳奇 李钦青 田雅娟 贺文彬 SHEN Yang;ZHANG Qi;ZHAO Jiaqi;LI Qinqing;TIAN Yajuan;HE Wenbin(Shanxi Institute of TCM, Taiyuan 030012, Shanxi, China;Shanxi College of TCM, Shanxi Key Lab of TCM Brain Disease, Shanxi University Key Lab of Brain Zang Manifestation, Taiyuan 030619, Shanxi, China)

机构地区：[1]山西省中医药研究院,山西太原030012 [2]山西中医药大学,中医脑病学山西省重点实验室&脑藏象学山西省高等学校重点实验室,山西太原030619

出　　处：《中华中医药学刊》2018年第2期319-322,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81273629,81473375)

摘　　要：阿尔兹海默病与帕金森病均是影响人类健康的神经退行性疾病,其发病机制较为复杂,但具有一定的共性,归纳总结为神经元的凋亡;小胶质细胞的调节作用;miRNA的表达;自噬过程的调节作用及P62蛋白的降解作用。通过对阿尔兹海默病与帕金森病的共性机制进行归纳,其优势在于针对部分既有阿尔兹海默病的临床表现,又有帕金森病临床表现的患者,可以采取同一种干预手段进行治疗,这将是对神经退行性疾病的治疗与研究的又一突破点。Alzheimer＇ s disease（AD） and Parkinson＇ s disease （PD） both affect human health and the pathogenesis of AD and PD is relatively complex. But there is common pathological mechanism which is summarized as neuron apopto- sis, the regulation of microglia role; the expression of micrornas ; autophagy process adjustment and P62 protein degrada- tion. Through the common mechanism of AD and PD induction, the author found that the advantage for patients with clin- ical manifestations of both AD and PD. The treatment can take the same kind of treatment and it will be a breakthrough of neurodegenerative diseases and research

关 键 词：阿尔兹海默病 帕金森病 神经退行性疾病 机制 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R749.16[医药卫生—临床医学]