基于体素水平度中心度分析失眠障碍脑功能网络  

Degree centrality analysis of brain functional network in insomnia disorder based on voxel

作　　者：张丹丹[1,2] 李中林 陈瑞[1,2] 王恩峰 邹智[1,2] 申延蕊 张红菊[3] 李永丽 

机构地区：[1]河南省人民医院放射科,河南郑州450000 [2]河南省神经病学影像诊断与研究重点实验室,河南郑州450000 [3]河南省人民医院神经内科,河南郑州450000 [4]河南省人民医院放射科健康管理中心,河南郑州450000

出　　处：《中国医学影像技术》2018年第2期195-199,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划(2017YFBl002502)、河南省自然科学基金(162300410285)、河南省科技厅科技攻关项目(1721023100115)、河南省医学科技攻关计划(201602193).

摘　　要：目的利用基于体素水平的度中心度(DC)探讨失眠障碍(ID)患者静息状态下大脑功能网络连接属性的改变。方法对年龄、性别及受教育程度相匹配的22例ID患者(ID组)和23名健康志愿者(正常对照组)进行静息态fMRI。采用匹兹堡睡眠质量指数(PSQI)量表、汉密尔顿焦虑量表、汉密尔顿抑郁量表对受试者睡眠情况及整体情绪状态进行评估。采用基于体素的DC方法分析fMRI数据,以t检验比较组内、组间参数。对ID组差异脑区的DC值分别与临床参数进行相关性分析。结果与正常对照组比较,ID组左侧海马旁回、左侧海马和双侧楔前叶DC值增强(P均<0.05),左侧枕中叶、左侧楔叶、左侧额下回和左侧额中回DC值减低(P均<0.05)。ID患者左侧海马DC值与PSQI评分呈负相关(r=-0.46,P=0.047)。结论ID患者静息态脑功能网络DC值存在多处异常,且左侧海马DC值异常与PSQI相关,可为ID的病理机制和临床研究提供影像学依据。Objective To explore the changes of brain functional network in insomnia disorder （ID） during resting-state with voxel-based degree centrality （DC）. Methods Forty-five subjects underwent resting-state fMRI scans, including 22 patients with ID （ID group） and 23 sex-, age-, and education-matched healthy volunteers （control group）. The subjects＂ sleep quality and emotion state were assessed with Pittsburgh sleep quality index （PSQI）, Hamilton anxiety scale and Hamilton depression scale. The resting-state fMRI data were analyzed with voxel-based DC. The intra- and inter-groups parameters were compared using t-test. Correlation analysis was performed between DC values of ID group and clinical parameters. Results Compared with control group, DC values increased in left parahippocampal gyrus, left hippocampus and bilateral precuneus （all P〈0.05）, while decreased in left middle occipital lobe, left precuneus, left inferior frontal gyrus and left middle frontal gyrus in ID group （all P〈O. 05）. DC values of the left hippocampus in ID patients showed significantly negative correlation with the score of Pittsburgh sleep quality index （r= --0.46, P=0. 047）. Conclusion ID patients have abnormal DC distribution of brain functional network, therefore providing basis for understanding pathophysiological mechanisms of ID.

关 键 词：失眠 体素 脑 功能网络 度中心度 磁共振成像 

分 类 号：R749.92[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]