低剂量化疗作用机制的研究进展  

Research progress on mechanism of low-dose chemotherapy

作　　者：梁语丝[1] 谭永刚[1] 邹华伟[1] LIANG Yusi;TAN Yonggang;ZOU Huawei(Department of Oncology, Shengjing Hospital of China Medical University ,Shenyang 110022 ,China)

机构地区：[1]中国医科大学附属盛京医院肿瘤科,沈阳110022

出　　处：《实用肿瘤学杂志》2017年第6期538-542,共5页Practical Oncology Journal

基　　金：国家自然科学基金资助项目(81472806)

摘　　要：化疗是肿瘤综合治疗的主要方式之一,多年来在肿瘤治疗中发挥着重要作用。但近年来低剂量化疗(Low-dose chemotherapy)利用其化疗药物的作用点,采取合理的给药方式和计划,且相对于最大耐受剂量化疗具有毒副反应小、患者耐受性明显提高、疗效更佳等优势,已逐渐成为临床中常用的治疗策略。本文就低剂量化疗的作用机制的研究进展做一系统综述。Chemotherapy is one of the main ways for comprehensive treatment of tumors,and has played an important role in tumor treatment for many years. However,in recent years,low-dose chemotherapy（ Low-dose chemotherapy） has gradually become a clinical treatment strategy commonly used to taken a reasonable mode of administration and planning,relative to the maximum tolerated dose of chemotherapy with small side effects,patient tolerance significantly improved,better efficacy and other. In this paper,the mechanism of low-dose chemotherapy on the progress is reviewed systematicly.

关 键 词：低剂量化疗 抗血管生成 细胞凋亡 

分 类 号：R730.53[医药卫生—肿瘤]