乙肝病毒感染状态及表面抗原/抗体水平与结肠癌分期和预后的关联  

Correlation Between States of Hepatitis B Virus Infection, Levels of Hepatitis B Surface Antigens/Antibodies and Staging, Prognosis of Colon Cancer

作　　者：林鑫[1] 刘进生[2] 

机构地区：[1]福建省立医院肿瘤内科,福州350001 [2]福建省立医院胃肠外科,福州350001

出　　处：《肿瘤防治研究》2018年第2期82-85,共4页Cancer Research on Prevention and Treatment

摘　　要：目的观察结肠癌患者乙肝病毒感染状态及表面抗原/抗体水平,分析其与结肠癌分期的关联,从而间接评估结肠癌患者合并乙型肝炎对其预后的影响。方法收集福建省立医院收治的85例结肠癌患者,采用SPSS16.0统计软件回顾性分析乙肝病毒感染状态对结肠癌浸润深度、区域淋巴结转移和远处转移的影响。结果乙肝病毒感染状态对结肠癌原发灶浸润深度(T)(P=0.331)和结肠癌区域淋巴结转移(N)的影响差异无统计学意义(P=0.098)。合并乙肝病毒阳性的结肠癌患者其区域淋巴结转移度明显低于乙肝病毒阴性的亚组(8.1%vs.17.8%),且无区域淋巴结转移的结肠癌患者血清中Hbs Ab水平较发生淋巴结转移的亚组患者明显升高(240.111 m IU/ml vs.178.161 m IU/ml)。乙肝病毒感染状态对结肠癌患者发生远处转移(M)以及肝转移的影响差异均具有统计学意义(均P<0.001)。不论是乙肝病毒感染还是乙肝疫苗相关的乙肝病毒阳性患者,肝转移发生率均显著低于乙肝病毒阴性的患者(P=0.039,P<0.001)。结论结肠癌合并乙肝病毒表面抗体水平高表达对区域淋巴结转移可能具有潜在的抑制作用。乙肝病毒阳性对结肠癌发生远处转移(尤其对肝转移)呈显著性负相关。乙肝病毒感染状态以及表面抗原/抗体水平显著性影响结肠癌患者的分期及预后。Objective To observe the states of hepatitis B virus infection and the expression levels of HBsAg and HBsAb in patients with colon cancer, and to analyze their correlation with the staging and prognosis of colon cancer. Methods We collected 85 cases of colon cancer treated in Fujian Provincial Hospital. SPSS 16.0 software was used to retrospectively study the possible influence of hepatitis B virus infection on the infiltration depth, regional lymph node metastasis and distant metastasis in patients with colon cancer. Results There was no statistically significant difference between the states of hepatitis B virus infection and the depth （T）, the regional lymph node metastasis （N） of colon cancer （P=0.331, P=0.098）. However, the metastatic disease of regional lymph node in subgroup of hepatitis-B-positive colon cancer was significantly lower than that in hepatitis-B-negative colon cancer（8.1% vs. 17.8%）. The level of serum HbsAb in patients without regional lymph node metastasis was higher than that with regional lymph node metastasis （240.111 mIU/ml vs. 178.161 mIU/ml）. There was statistically significant difference between the states of hepatitis B virus infection and the distant metastasis （M）, liver metastasis （P〈0.001）. Meanwhile, both subgroups of positive hepatitis B with infection and vaccine showed significant statistical differences when comparing with hepatitis B negative in the event of the probability of liver metastases （P=0.039 and P〈0.001）. Conclusion The high expression of serum HBsAb might have a potential inhibitory effect on region lymph node metastases in patients with colon cancer. The state of positive hepatitis B expression shows a significantly negative correlation with distant metastases, especially liver metastases. The states of hepatitis B virus infection and the levels with serum HbsAg/HbsAb influence the staging and prognosis of patients with colon cancer significantly.

关 键 词：结肠癌 乙肝病毒感染状态 淋巴结转移 肝转移 

分 类 号：R735.35[医药卫生—肿瘤]