基于MR Dixon技术的肝脏脂肪半定量分析及其临床意义  

Semi-quantitative analysis of hepatic fat in MR using Dixon technique and its clinical significance

作　　者：柳勇[1,2] 单奔[2] 周寒松 于冬洋[2] 董浩 胡春洪[1] 

机构地区：[1]苏州大学附属第一医院放射科,江苏苏州215006 [2]淮安市第二人民医院放射科,江苏淮安223002

出　　处：《实用放射学杂志》2018年第2期291-295,共5页Journal of Practical Radiology

摘　　要：目的 对肝脏脂肪分数（HFF）进行测量，并分析其与各种临床指标的相关性，研究其临床意义。方法 对95例成人进行MR Dixion序列扫描，测量其肝脏HFF，据此将其分为肝脏高脂肪组及低脂肪肝组。测量腹部皮下脂肪面积（SA）、腹腔内脏脂肪面积（VA）及腹部总脂肪面积（TA）。检查空腹血糖（FPG）、总胆固醇（TC）、甘油三酯（TG）、低密度胆固醇（LDL-c）、高密度胆固醇（HDL-c），并记录患者年龄、测量血压、计算体质量指数（BMI）。结果 肝脏高脂肪组的FPG、TG、LDL-c、收缩压、舒张压、BMI、VA、TA、腹腔内脏脂肪面积比例（VFP）均显著高于低脂肪组，而其腹部皮下脂肪面积比例（SFP）低于后者（P＜0.05）。FPG、TG、LDL-c、VA、TA、VFP、年龄、BMI与HFF正相关（r=0.354、0.370、0.415、0.299、0.285、0.238、0.203、0.221，P＜0.05）。结论 基于MR Dixon技术的肝脏脂肪半定量分析能够反映肝脏脂肪浸润程度，可作为非酒精性脂肪肝早期诊断及治疗评估的量化参考指标。Objective To investigate the correlation between hepatic fat fraction （HFF） and some clinical indicators by measuring HFF and summarize its clinical significance.Methods A total of 95 patients were included in this study.MR data were acquired with Dixon technique, and the HFF of liver were measured.According to the H FF, all patients were divided into high-fat group and low-fat group.Subcutaneous fat area （SA） ,visceral fat area {VA） and total fat area （TA） were also measured. The age of patients, blood pressure, fasting blood glucose （FPG）, total cholesterol （TC）, triglyceride （TG）, low density cholesterol （LDL-c） and high density cholesterol （ HDL-c ） were recorded and the body mass index （BMI） was calculated.Results The levels of FPG, TG, LDL-c, systolic blood pressure,diastolic blood pressure,BMI,VA ,TA and visceral fat percentage （VFP） in high-fat group were significantly higher than those in low-fat group （P 〈0.05）, while the abdominal subcutaneous fat percentage （SFP） was significantly lower than that in low-fat group （P〈0.05）. HFF was positively co rrelated with FPG, TG, LDL-c, VA, TA, VFP, age and BMI （ r =0.354, 0.370, 0.415, 0.299,0.285, 0.238,0.203,0.221, respectively; P（0.05）.Condusion Semi-quantitative analysis of hepatic fat using MR Dixon technique can reflect the degree of hepatic fatty infiltration, and can be used as a quantitative indicator for early diagnosis and treatment evaluation of nonalcoholic fatty liver disease.

关 键 词：非酒精性脂肪性肝病 脂肪分数 磁共振成像 

分 类 号：R575[医药卫生—消化系统] R445.2[医药卫生—内科学]