肝动脉化疗栓塞联合灌注三氧化二砷治疗原发性肝癌  

Preliminary observation of hepatic arterial chemoembolization combined with arsenic trioxide injection in treatment of primary liver cancer

作　　者：季峻松 陈婷 王辉[1] 王晨怡 殷浩[2] 傅志仁[2] 

机构地区：[1]上海长征医院闸北分院肝移植科,上海200070 [2]上海长征医院肝移植科,上海200003

出　　处：《实用医学杂志》2018年第2期251-253,共3页The Journal of Practical Medicine

基　　金：上海市闸北区科研课题(编号:2013QN03)

摘　　要：目的观察及分析对于原发性肝癌患者采取肝动脉化疗栓塞联合灌注三氧化二砷治疗方案的效果。方法研究对象为90例原发性肝癌患者,均为在2012年1月至2016年6月期间接受治疗的病例。将患者分为研究组以及参照组两组,实施不同的治疗方案。即参照组患者实施肝动脉化疗栓塞治疗,研究组病例在此基础上联合灌注三氧化二砷治疗,观察及比较效果情况。结果通过比较近期疗效,两组间的比较差异无统计学意义(P>0.05);比较1年生存率,研究组优于参照组(P<0.05);两组间的不良反应情况比较差异无统计学意义(P>0.05);对比两组的生存质量改善情况,研究组更具优势,P<0.05。结论采取肝动脉化疗栓塞联合灌注三氧化二砷治疗原发性肝癌,可以提升1年的生存率,具有良好远期生存率,同时不存在明显的不良反应,可以相对提升患者生存质量。Objective This paper aims to observe and analyze the effect of hepatic arterial chemoemboliza- tion combined with arsenic trioxide injection in the patients with primary liver cancer. Methods This study includ- ed Ninety patients with primary liver cancer who were treated in our hospital from January 2013 to June 2016. The patients were divided into the study group and control group and the two groups were given different treatment proto- cols. The patients in the control group were treated with hepatic arterial ehemoemholization and the patients in the study group were treated with arsenic trioxide injection. On the basis of the treatment effect was observed and com- pared. Results There was no significant difference between the two groups in recent curative effect （P 〉 0.05 ） ; the study group had higher one year survival rate than the control group （P 〈 0.05 ）. There was no significant differ- ence between the two groups in adverse reactions （P 〉 0.05 ） ; the study group was superior to the control group in terms of improvement of quality of life （P 〈 0.05）. Conclusions Hepatic arterial chemoembolization combined with arsenic trioxide injection can improve one year survival rate of primary liver cancer patients, and provide good long-term survival rate without obvious adverse reactions, and improve quality of life of patients.

关 键 词：肝动脉化疗栓塞 三氧化二砷 原发性肝癌 疗效观察 

分 类 号：R735.7[医药卫生—肿瘤]