伊立替康化疗方案联合高频热疗治疗晚期结直肠癌的临床研究  

Observation of FOLFIRI combined with high-frequency hyperthermia in treating advanced colorectal cancer

作　　者：周翡[1] 张海燕 王静珏 朱怡雯[1] 董笑[1] 李宁[1] 李琦[1] 

机构地区：[1]上海交通大学附属第一人民医院肿瘤中心,上海200080

出　　处：《安徽医药》2018年第3期470-474,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的观察FOLFIRI联合高频热疗治疗晚期结直肠癌的近期疗效、毒性反应和生活质量。方法共入组55例晚期结直肠癌患者,观察组(24例)采用FOLFIRI化疗联合高频热疗,共4个周期。对照组(31例)采用FOLFIRI化疗,共4个周期。治疗结束后评价疗效、毒性反应和生活质量。结果两组的近期疗效分别为50.0%和38.7%,毒性反应相近,差异无统计学意义(P>0.05)。但观察组的生活质量较对照组显著提高(P<0.05)。结论 FOLFIRI联合高频热疗治疗晚期结直肠癌生活质量明显改善,毒副反应可耐受。Objective To evaluate clinical efficacy,side effects and life quality of FOLFIRI combined with high-frequency hyperthermia in treating the patients with advanced colorectal cancer.Methods Fifty-five patients with advanced colorectal cancer were assigned into two groups.The 24 cases in the experimental group were treated with FOLFIRI and high-frequency hyperthermia while the 31 cases in the control group were treated with FOLFIRI.After the treatment for four cycles,clinical efficacy,side effects and life quality were compared between the two groups.Results Response rates in the experimental group and the control group were 50.0% and 38.7%,respectively.The toxic effect was similar and the difference was not statistically significant(P > 0.05).But the life quality was increased significantly in the experimental group(P < 0.05).Conclusions FOLFIRI combined with high-frequency hyperthermia increases life quality of the patients with advanced colorectal cancer and side effects can be tolerated.

关 键 词：晚期结直肠癌 化疗 高频热疗 生活质量 

分 类 号：R735.34[医药卫生—肿瘤]