ⅠB2～ⅡA期宫颈癌患者术后化疗时机对临床预后的影响  

The effect of postoperative chemotherapy timing on the prognosis of patients with stage ⅠB2-ⅡA cervical cancer

作　　者：王利霞 韩利伟 任少达 

机构地区：[1]南阳南石医院妇产科,河南南阳473000 [2]聊城市人民医院妇产科,山东聊城252002

出　　处：《安徽医药》2018年第3期486-490,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨宫颈癌患者术后化疗时机对临床预后的影响。方法回顾性收集ⅠB2~ⅡA期宫颈癌患者167例,所有患者均行"PiverⅢ型广泛性子宫切除+盆腔淋巴结切除术",术后进行化疗,根据患者术后至化疗时间,将分为早期化疗组(术后至化疗时间≤3周)和晚期化疗组(术后至化疗时间>3周),其中早期化疗组89例,晚期化疗组78例,主要观察指标包括:术后并发症、无进展生存期、复发率、病死率、健康相关的生存质量(SF-36)。结果与晚期化疗组相比,早期化疗组患者术后复发率显著降低(12.36%vs 24.36%,P<0.05);术后1年SF-36明显提高[(76.82±8.57)vs(70.75±9.12),P<0.05];无进展生存期显著延长(P<0.05)。两组患者死亡率和术后并发症等均差异无统计学意义。结论ⅠB2~ⅡA期宫颈癌患者术后早期化疗有助于改善临床预后。Objective To investigate the effect of postoperative chemotherapy timing on the prognosis of patients with cervical cancer.Methods A hundred and sixty-seven patients with cervical cancer of stageⅠB2-ⅡA were retrospectively enrolled in this study.All the patients received " Piver Ⅲ extensive hysterectomy and pelvic lymph node resection" and postoperative chemotherapy.According to the time of chemotherapy starting since the operation,all patients were assigned into an early chemotherapy group(the time of chemotherapy starting since the operation shorter than or equal to 3 weeks) and a late chemotherapy group(the time of chemotherapy starting since the operation longer than 3 weeks).There were 89 patients in the early chemotherapy group and 78 patients in the late chemotherapy group.The primary outcomes included postoperative complications,progression free survival,recurrence rate,case fatality rate and health related quality of life(SF-36).Results When compared with the late chemotherapy group,patients in the early chemotherapy group got a significantly lower recurrence rate(12.36% vs 24.36%,P < 0.05),an elevated level of 1-year health related quality of life(SF-36) [(76.82 ± 8.57) vs(70.75 ± 9.12),P < 0.05],and a longer duration of progression free survival(P < 0.05).There were no significant differences between the two groups in mortality and postoperative complications.Conclusions Early postoperative chemotherapy in patients with ⅠB2-ⅡA cervical cancer is helpful to improve the clinical prognosis.

关 键 词：宫颈癌 术后 化疗 时机 临床预后 

分 类 号：R737.33[医药卫生—肿瘤]