CK18、CK19在前列腺癌中的表达及其临床意义  

Expression and clinical significance of cytokeratin 18,19 in prostate cancer

作　　者：张超[1] 殷波[1] 

机构地区：[1]中国医科大学附属盛京医院泌尿外科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2018年第5期737-740,共4页Journal of Modern Oncology

摘　　要：目的:研究细胞角蛋白18、19(CK18、CK19)在前列腺癌(prostate cancer,PCa)组织中的表达及临床意义。方法:根据以Gleason评分为标准确定的临床危险度,将选择的65例前列腺癌标本分为高危组和低危组。应用免疫组化SP方法检测CK18、CK19在前列腺癌组织中的表达,并采用统计学方法分析CK18、CK19的表达与前列腺癌临床危险度的关系。结果:CK18在高危组、低危组前列腺癌中的阳性表达率分别是31.4%(11/35)、60.0%(15/25)(P=0.028);CK19在高危组、低危组前列腺癌中的阳性表达率分别是33.3%(11/33)、65.5%(19/29)(P=0.011);CK18的表达水平与病情进展到去势抵抗型前列腺癌阶段(castration-resistant prostate cancer,CRPC)的时间存在一定关系:在阳性表达组和阴性表达组中,进展到CRPC阶段的时间均值分别为4.82个月和6.95个月(t=2.501,P=0.018),结果存在统计学差异。结论:在前列腺癌中,随着临床危险度的增高,CK18、CK19的表达水平呈现降低的趋势;且随着CK18表达水平的下调,进展到CRPC阶段的时间缩短,这对于前列腺癌的辅助诊断、指导治疗及预后判断有一定的指导意义。Objective To study the expression of cytokeratin （ CK） 18 and CK19 in prostate cancer and further explore the clinical significance. Methods： Based on the risk stratification determined by Gleason score,65 cases of PCa were divided into high - risk group and low - risk group. The immunohistochemical staining was applied to detect the expression of CK18 and CK19 in PCa tissue samples. The further analysis was performed to determine the possible relationship between the expression of CK18 and CK19 with the clinical risk stratification of PCa. Results： The posi-tive expression rate of CK18 was 31.4% （11/35） in high - risk group and 60. 0% （15/25） in low - risk group （ P =0. 028） . The positive expression rate of CK19 was 33. 3% （ 11/33） in high - risk group and 65. 5% （ 19/29） in low - risk group （ P = 0. 011）. The expression level of CK18 might be related to the time period of progression to the CRPC （ castration - resistant prostate cancer） stage. The mean value of the time period of progression to the CRPC phase was 4. 82 months in the positive expression group and 6. 95 months in the negative expression group, respective- ij（t = ： 2. 501 = 0. 018 ） . Conclusion： In PCa, the downregulation of CK19 and CK18 was associated with higherclinical risk degree,and the downregulation of CK18 was associated with shortened time period of progression to CRPC. Our data may facilitate the diagnosis,treatment and prognosis assessment of prostate cancer.

关 键 词：前列腺癌 细胞角蛋白 去势抵抗型前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]