射频消融术联合索拉菲尼靶向治疗对晚期肝癌患者的疗效研究  

Efficacy of radiofrequency ablation combined with Sola Feeney targeted therapy in patients with advanced liver cancer

作　　者：向爱生 魏瑞[1] XIANG Aisheng;WEI Rui;Department of Oncology;Xiangya Hospital Central South University;

机构地区：[1]中南大学湘雅医院肿瘤科,长沙410008

出　　处：《检验医学与临床》2018年第4期482-484,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨射频消融术联合索拉菲尼靶向治疗对晚期肝癌患者生活质量及远期生存的影响。方法选择该院2011年6月至2014年6月晚期肝癌患者78例,按照随机数字表法分为观察组(39例)与对照组(39例)。观察组患者采用射频消融术联合索拉菲尼靶向治疗,对照组使用单纯索拉菲尼靶向治疗。比较2组患者疾病控制率(DCR),治疗前后免疫功能和生活质量的改善情况,及随访1、2年的生存情况。结果观察组患者DCR(69.23%)高于对照组(48.72%),差异有统计学意义(P<0.05);观察组治疗后CD3^+、CD4^+、CD4^+/CD8^+高于对照组,差异有统计学意义(P<0.05);观察组治疗后社会功能、情感功能、躯体功能、认知功能及角色功能评分均高于对照组,差异有统计学意义(P<0.05);观察组1年生存率(66.67%)和2年生存率(53.85%)高于对照组(46.15%和30.77%),差异有统计学意义(P<0.05)。结论射频消融术联合索拉菲尼靶向治疗可改善晚期肝癌患者的生活质量,且延长生存时间,具有重要的临床意义。Objective To investigate the effect of radiofrequency ablation combined with Sola Feeney targeted therapy on quality of life and long-term survival in patients with advanced liver cancer.Methods A total of 78 patients with advanced liver cancer treated in our hospital from June 2011 to June 2014 were divided into observation group 39 cases and control group 39 cases according to the random number table method.The observation group was treated with radiofrequency ablation combined with Sola Feeney targeted therapy,while the control group was only treated with Sola Feeney targeted therapy.The DCR rate was compared between the two groups before and after treatment.The immune function and quality of life were improved,and the survival rates of the patients were followed up for 1 and 2 years.Results The observation group DCR（69.23%）was higher than that of the control group（48.72%）（P〈0.05）;the observation group after treatment CD3~＋,CD4~＋,CD4~＋/CD8~＋ were higher than those of the control group（P〈0.05）;the observation group after treatment,social function,emotional function,physical function,cognitive function and role function score were higher than those of those of the control group（P〈0.05）;the observation group 1 years survival rate（66.67%）and 2 year survival rate（53.85%）were higher than those of the control group 1 years survival rate（46.15%）and 2 year survival rate（30.77%）（P〈0.05）.Conclusion Radiofrequency ablation combined with Sola Feeney targeted therapy can improve the quality of life and prolong the survival time of advanced liver cancer.

关 键 词：射频消融术 索拉菲尼 肝癌 晚期 

分 类 号：R733[医药卫生—肿瘤]