口腔黏膜生物黏附性材料的研究进展  

Progress of Buccal Bioadhesive Polymers

作　　者：刘仁亮 马晋隆[1] 倪睿[1] 史家骏[1] 徐驿 

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2018年第2期149-155,共7页Chinese Journal of Pharmaceuticals

摘　　要：口腔给药是一种较为方便的给药途径,可用于局部和全身给药。口腔黏膜黏附给药是指由含有药物的生物黏附性材料制成的载体持久地黏附于黏膜,药物能从载体内持续释放的给药系统。口腔黏膜黏附剂型中最为关键的是生物黏附性材料。本文简要介绍了口腔黏膜的结构以及黏膜黏附的基本情况,综述了常用于口腔黏膜给药的生物黏附性材料,并总结了部分已上市的口腔黏膜黏附制剂。Buccal delivery is considered a convenient route for the administration of drugs intended for both local and systemic delivery. Buccal mucoadhesive drug delivery systems （BMDDS） are drug-loading carriers with the buccal bioadhesive function, which can persistently adhere to oral mucosa and thus continue to release drug to administration place. Buccal bioadhesive polymer is the crucial point for BMDDS to achieve sustained adherence and release. This paper illustrates the similarities and differences between buccal bioadhesive polymers and other bioadhesive polymers, lists the advantages of BMDDS, describes characteristics of oral mucosa and the basic situation of mucoadhesion, reviews the bioadhesive polymers commonly used in buccal mucoadhesive delivery and summaries some of the commercial buccal mucoadhesive formulations.

关 键 词：口腔黏膜 口腔黏膜黏附给药系统 生物黏附性材料 综述 

分 类 号：R944.9[医药卫生—药剂学]